The role of EGFR signaling in age-related osteoporosis in mouse cortical bone.
Liu G, Xie Y, Su J, Qin H, Wu H, Li K, Yu B, Zhang X.
Liu G, et al.
FASEB J. 2019 Oct;33(10):11137-11147. doi: 10.1096/fj.201900436RR. Epub 2019 Jul 12.
FASEB J. 2019.
PMID: 31298955
Down-regulated EGFR signaling plays a physiologically significant role during aging by reducing Ezh2 expression, leading to the senescence of osteoprogenitors and the decline in bone formation on the endosteal surface of cortical bone.-Liu, G., Xie, Y., Su, J., Qin, …
Down-regulated EGFR signaling plays a physiologically significant role during aging by reducing Ezh2 expression, leading to the senescence o …