Rosen N - Search Results

1

HER2-Mediated Internalization of Cytotoxic Agents in ERBB2 Amplified or Mutant Lung Cancers.

Li BT, Michelini F, Misale S, Cocco E, Baldino L, Cai Y, Shifman S, Tu HY, Myers ML, Xu C, Mattar M, Khodos I, Little M, Qeriqi B, Weitsman G, Wilhem CJ, Lalani AS, Diala I, Freedman RA, Lin NU, Solit DB, Berger MF, Barber PR, Ng T, Offin M, Isbell JM, Jones DR, Yu HA, Thyparambil S, Liao WL, Bhalkikar A, Cecchi F, Hyman DM, Lewis JS, Buonocore DJ, Ho AL, Makker V, Reis-Filho JS, Razavi P, Arcila ME, Kris MG, Poirier JT, Shen R, Tsurutani J, Ulaner GA, de Stanchina E, Rosen N, Rudin CM, Scaltriti M. Li BT, et al. Among authors: rosen n. Cancer Discov. 2020 May;10(5):674-687. doi: 10.1158/2159-8290.CD-20-0215. Epub 2020 Mar 25. Cancer Discov. 2020. PMID: 32213539 Free PMC article.

2

Identification of a geldanamycin dimer that induces the selective degradation of HER-family tyrosine kinases.

Zheng FF, Kuduk SD, Chiosis G, Münster PN, Sepp-Lorenzino L, Danishefsky SJ, Rosen N. Zheng FF, et al. Among authors: rosen n. Cancer Res. 2000 Apr 15;60(8):2090-4. Cancer Res. 2000. PMID: 10786665

3

Modulation of Hsp90 function by ansamycins sensitizes breast cancer cells to chemotherapy-induced apoptosis in an RB- and schedule-dependent manner. See: E. A. Sausville, Combining cytotoxics and 17-allylamino, 17-demethoxygeldanamycin: sequence and tumor biology matters, Clin. Cancer Res., 7: 2155-2158, 2001.

Münster PN, Basso A, Solit D, Norton L, Rosen N. Münster PN, et al. Among authors: rosen n. Clin Cancer Res. 2001 Aug;7(8):2228-36. Clin Cancer Res. 2001. PMID: 11489796

4

The tyrosine kinase inhibitor ZD1839 ("Iressa") inhibits HER2-driven signaling and suppresses the growth of HER2-overexpressing tumor cells.

Moasser MM, Basso A, Averbuch SD, Rosen N. Moasser MM, et al. Among authors: rosen n. Cancer Res. 2001 Oct 1;61(19):7184-8. Cancer Res. 2001. PMID: 11585753

5

Ansamycin antibiotics inhibit Akt activation and cyclin D expression in breast cancer cells that overexpress HER2.

Basso AD, Solit DB, Munster PN, Rosen N. Basso AD, et al. Among authors: rosen n. Oncogene. 2002 Feb 14;21(8):1159-66. doi: 10.1038/sj.onc.1205184. Oncogene. 2002. PMID: 11850835 Free PMC article.

6

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts.

Solit DB, Zheng FF, Drobnjak M, Münster PN, Higgins B, Verbel D, Heller G, Tong W, Cordon-Cardo C, Agus DB, Scher HI, Rosen N. Solit DB, et al. Among authors: rosen n. Clin Cancer Res. 2002 May;8(5):986-93. Clin Cancer Res. 2002. PMID: 12006510

7

Akt forms an intracellular complex with heat shock protein 90 (Hsp90) and Cdc37 and is destabilized by inhibitors of Hsp90 function.

Basso AD, Solit DB, Chiosis G, Giri B, Tsichlis P, Rosen N. Basso AD, et al. Among authors: rosen n. J Biol Chem. 2002 Oct 18;277(42):39858-66. doi: 10.1074/jbc.M206322200. Epub 2002 Aug 9. J Biol Chem. 2002. PMID: 12176997 Free article.

8

Total synthesis as a resource in the discovery of potentially valuable antitumor agents: cycloproparadicicol.

Yamamoto K, Garbaccio RM, Stachel SJ, Solit DB, Chiosis G, Rosen N, Danishefsky SJ. Yamamoto K, et al. Among authors: rosen n. Angew Chem Int Ed Engl. 2003 Mar 17;42(11):1280-4. doi: 10.1002/anie.200390329. Angew Chem Int Ed Engl. 2003. PMID: 12645064 No abstract available.

9

Inhibition of heat shock protein 90 function down-regulates Akt kinase and sensitizes tumors to Taxol.

Solit DB, Basso AD, Olshen AB, Scher HI, Rosen N. Solit DB, et al. Among authors: rosen n. Cancer Res. 2003 May 1;63(9):2139-44. Cancer Res. 2003. PMID: 12727831

10

Angiogenesis impairment in Id-deficient mice cooperates with an Hsp90 inhibitor to completely suppress HER2/neu-dependent breast tumors.

de Candia P, Solit DB, Giri D, Brogi E, Siegel PM, Olshen AB, Muller WJ, Rosen N, Benezra R. de Candia P, et al. Among authors: rosen n. Proc Natl Acad Sci U S A. 2003 Oct 14;100(21):12337-42. doi: 10.1073/pnas.2031337100. Epub 2003 Oct 2. Proc Natl Acad Sci U S A. 2003. PMID: 14526102 Free PMC article.

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