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239 results

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A randomized proof-of-mechanism trial applying the 'fast-fail' approach to evaluating κ-opioid antagonism as a treatment for anhedonia.
Krystal AD, Pizzagalli DA, Smoski M, Mathew SJ, Nurnberger J Jr, Lisanby SH, Iosifescu D, Murrough JW, Yang H, Weiner RD, Calabrese JR, Sanacora G, Hermes G, Keefe RSE, Song A, Goodman W, Szabo ST, Whitton AE, Gao K, Potter WZ. Krystal AD, et al. Among authors: iosifescu d. Nat Med. 2020 May;26(5):760-768. doi: 10.1038/s41591-020-0806-7. Epub 2020 Mar 30. Nat Med. 2020. PMID: 32231295 Free PMC article. Clinical Trial.
Anhedonia in melancholic and non-melancholic depressive disorders.
Fletcher K, Parker G, Paterson A, Fava M, Iosifescu D, Pizzagalli DA. Fletcher K, et al. Among authors: iosifescu d. J Affect Disord. 2015 Sep 15;184:81-8. doi: 10.1016/j.jad.2015.05.028. Epub 2015 May 21. J Affect Disord. 2015. PMID: 26074016 Free PMC article.
Corticotropin-Releasing Factor Receptor 1 Antagonism Is Ineffective for Women With Posttraumatic Stress Disorder.
Dunlop BW, Binder EB, Iosifescu D, Mathew SJ, Neylan TC, Pape JC, Carrillo-Roa T, Green C, Kinkead B, Grigoriadis D, Rothbaum BO, Nemeroff CB, Mayberg HS. Dunlop BW, et al. Among authors: iosifescu d. Biol Psychiatry. 2017 Dec 15;82(12):866-874. doi: 10.1016/j.biopsych.2017.06.024. Epub 2017 Jul 4. Biol Psychiatry. 2017. PMID: 28793974 Free PMC article. Clinical Trial.
Placebo Effects Across Self-Report, Clinician Rating, and Objective Performance Tasks Among Women With Post-Traumatic Stress Disorder: Investigation of Placebo Response in a Pharmacological Treatment Study of Post-Traumatic Stress Disorder.
Hodgins GE, Blommel JG, Dunlop BW, Iosifescu D, Mathew SJ, Neylan TC, Mayberg HS, Harvey PD. Hodgins GE, et al. Among authors: iosifescu d. J Clin Psychopharmacol. 2018 Jun;38(3):200-206. doi: 10.1097/JCP.0000000000000858. J Clin Psychopharmacol. 2018. PMID: 29505471 Free PMC article. Clinical Trial.
DNA methylation levels are associated with CRF1 receptor antagonist treatment outcome in women with post-traumatic stress disorder.
Pape JC, Carrillo-Roa T, Rothbaum BO, Nemeroff CB, Czamara D, Zannas AS, Iosifescu D, Mathew SJ, Neylan TC, Mayberg HS, Dunlop BW, Binder EB. Pape JC, et al. Among authors: iosifescu d. Clin Epigenetics. 2018 Nov 3;10(1):136. doi: 10.1186/s13148-018-0569-x. Clin Epigenetics. 2018. PMID: 30390684 Free PMC article. Clinical Trial.
The first implementation of the NIMH FAST-FAIL approach to psychiatric drug development.
Krystal AD, Pizzagalli DA, Mathew SJ, Sanacora G, Keefe R, Song A, Calabrese J, Goddard A, Goodman W, Lisanby SH, Smoski M, Weiner R, Iosifescu D, Nurnberger J Jr, Szabo S, Murrough J, Shekhar A, Potter W. Krystal AD, et al. Among authors: iosifescu d. Nat Rev Drug Discov. 2018 Dec 28;18(1):82-84. doi: 10.1038/nrd.2018.222. Nat Rev Drug Discov. 2018. PMID: 30591715 Free PMC article. No abstract available.
Sex differences in response to ketamine as a rapidly acting intervention for treatment resistant depression.
Freeman MP, Papakostas GI, Hoeppner B, Mazzone E, Judge H, Cusin C, Mathew S, Sanacora G, Iosifescu D, DeBattista C, Trivedi MH, Fava M. Freeman MP, et al. Among authors: iosifescu d. J Psychiatr Res. 2019 Mar;110:166-171. doi: 10.1016/j.jpsychires.2019.01.010. Epub 2019 Jan 8. J Psychiatr Res. 2019. PMID: 30641350 Free PMC article. Clinical Trial.
Psychophysiological treatment outcomes: Corticotropin-releasing factor type 1 receptor antagonist increases inhibition of fear-potentiated startle in PTSD patients.
Jovanovic T, Duncan EJ, Kaye J, Garza K, Norrholm SD, Inslicht SS, Neylan TC, Mathew SJ, Iosifescu D, Rothbaum BO, Mayberg HS, Dunlop BW. Jovanovic T, et al. Among authors: iosifescu d. Psychophysiology. 2020 Jan;57(1):e13356. doi: 10.1111/psyp.13356. Epub 2019 Feb 26. Psychophysiology. 2020. PMID: 30807663 Free PMC article. Clinical Trial.
239 results