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Photocatalytic [2 + 2] Cycloaddition in DNA-Encoded Chemistry.
Kölmel DK, Ratnayake AS, Flanagan ME, Tsai MH, Duan C, Song C. Kölmel DK, et al. Among authors: ratnayake as. Org Lett. 2020 Apr 17;22(8):2908-2913. doi: 10.1021/acs.orglett.0c00574. Epub 2020 Apr 2. Org Lett. 2020. PMID: 32239950
Photoredox cross-electrophile coupling in DNA-encoded chemistry.
Kölmel DK, Ratnayake AS, Flanagan ME. Kölmel DK, et al. Among authors: ratnayake as. Biochem Biophys Res Commun. 2020 Dec 3;533(2):201-208. doi: 10.1016/j.bbrc.2020.04.028. Epub 2020 May 12. Biochem Biophys Res Commun. 2020. PMID: 32414574
Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS).
Ratnayake AS, Flanagan ME, Foley TL, Hultgren SL, Bellenger J, Montgomery JI, Lall MS, Liu B, Ryder T, Kölmel DK, Shavnya A, Feng X, Lefker B, Byrnes LJ, Sahasrabudhe PV, Farley KA, Chen S, Wan J. Ratnayake AS, et al. Bioorg Med Chem. 2021 Jul 1;41:116205. doi: 10.1016/j.bmc.2021.116205. Epub 2021 May 11. Bioorg Med Chem. 2021. PMID: 34000509
Merging C(sp3)-H activation with DNA-encoding.
Fan Z, Zhao S, Liu T, Shen PX, Cui ZN, Zhuang Z, Shao Q, Chen JS, Ratnayake AS, Flanagan ME, Kölmel DK, Piotrowski DW, Richardson P, Yu JQ. Fan Z, et al. Among authors: ratnayake as. Chem Sci. 2020 Sep 7;11(45):12282-12288. doi: 10.1039/d0sc03935g. Chem Sci. 2020. PMID: 34094436 Free PMC article.
Kinetically guided radical-based synthesis of C(sp3)-C(sp3) linkages on DNA.
Wang J, Lundberg H, Asai S, Martín-Acosta P, Chen JS, Brown S, Farrell W, Dushin RG, O'Donnell CJ, Ratnayake AS, Richardson P, Liu Z, Qin T, Blackmond DG, Baran PS. Wang J, et al. Among authors: ratnayake as. Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6404-E6410. doi: 10.1073/pnas.1806900115. Epub 2018 Jun 26. Proc Natl Acad Sci U S A. 2018. PMID: 29946037 Free PMC article.
Optimization of Tubulysin Antibody-Drug Conjugates: A Case Study in Addressing ADC Metabolism.
Tumey LN, Leverett CA, Vetelino B, Li F, Rago B, Han X, Loganzo F, Musto S, Bai G, Sukuru SC, Graziani EI, Puthenveetil S, Casavant J, Ratnayake A, Marquette K, Hudson S, Doppalapudi VR, Stock J, Tchistiakova L, Bessire AJ, Clark T, Lucas J, Hosselet C, O'Donnell CJ, Subramanyam C. Tumey LN, et al. ACS Med Chem Lett. 2016 Jun 22;7(11):977-982. doi: 10.1021/acsmedchemlett.6b00195. eCollection 2016 Nov 10. ACS Med Chem Lett. 2016. PMID: 27882194 Free PMC article.
40 results