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KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer.
Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen TY, Lin YH, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG. Alam H, et al. Among authors: kumar m. Cancer Cell. 2020 Apr 13;37(4):599-617.e7. doi: 10.1016/j.ccell.2020.03.005. Epub 2020 Apr 2. Cancer Cell. 2020. PMID: 32243837 Free PMC article.
BAP1 Is a Novel Target in HPV-Negative Head and Neck Cancer.
Liu X, Kumar M, Yang L, Molkentine DP, Valdecanas D, Yu S, Meyn RE, Heymach JV, Skinner HD. Liu X, et al. Among authors: kumar m. Clin Cancer Res. 2018 Feb 1;24(3):600-607. doi: 10.1158/1078-0432.CCR-17-1573. Epub 2017 Nov 7. Clin Cancer Res. 2018. PMID: 29113987 Free PMC article.
Integrative Analysis Identifies a Novel AXL-PI3 Kinase-PD-L1 Signaling Axis Associated with Radiation Resistance in Head and Neck Cancer.
Skinner HD, Giri U, Yang LP, Kumar M, Liu Y, Story MD, Pickering CR, Byers LA, Williams MD, Wang J, Shen L, Yoo SY, Fan YH, Molkentine DP, Beadle BM, Meyn RE, Myers JN, Heymach JV. Skinner HD, et al. Among authors: kumar m. Clin Cancer Res. 2017 Jun 1;23(11):2713-2722. doi: 10.1158/1078-0432.CCR-16-2586. Epub 2017 May 5. Clin Cancer Res. 2017. PMID: 28476872 Free PMC article.
Inhibition of histone acetyltransferase function radiosensitizes CREBBP/EP300 mutants via repression of homologous recombination, potentially targeting a gain of function.
Kumar M, Molkentine D, Molkentine J, Bridges K, Xie T, Yang L, Hefner A, Gao M, Bahri R, Dhawan A, Frederick MJ, Seth S, Abdelhakiem M, Beadle BM, Johnson F, Wang J, Shen L, Heffernan T, Sheth A, Ferris RL, Myers JN, Pickering CR, Skinner HD. Kumar M, et al. Nat Commun. 2021 Nov 3;12(1):6340. doi: 10.1038/s41467-021-26570-8. Nat Commun. 2021. PMID: 34732714 Free PMC article.
p16 Represses DNA Damage Repair via a Novel Ubiquitin-Dependent Signaling Cascade.
Molkentine DP, Molkentine JM, Bridges KA, Valdecanas DR, Dhawan A, Bahri R, Hefner AJ, Kumar M, Yang L, Abdelhakiem M, Pifer PM, Sandulache V, Sheth A, Beadle BM, Thames HD, Mason KA, Pickering CR, Meyn RE, Skinner HD. Molkentine DP, et al. Among authors: kumar m. Cancer Res. 2022 Mar 1;82(5):916-928. doi: 10.1158/0008-5472.CAN-21-2101. Cancer Res. 2022. PMID: 34965932 Free PMC article.
[No title available]
[No authors listed] [No authors listed] PMID: 34700651
Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins.
Kumar M, Kong K, Javier RT. Kumar M, et al. J Virol. 2014 Dec;88(24):14268-77. doi: 10.1128/JVI.02324-14. Epub 2014 Sep 24. J Virol. 2014. PMID: 25253337 Free PMC article.
We recently reported that the E4-ORF1 protein from subgroup D human adenovirus type 9 upregulates and oncogenically activates PI3K by a novel mechanism involving separate interactions of E4-ORF1 with cellular discs large 1 (Dlg1) and PI3K to form a ternary complex that translocat …
We recently reported that the E4-ORF1 protein from subgroup D human adenovirus type 9 upregulates and oncogenically activates PI3K by a nove …
11,192 results
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