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Loss of FHL1 induces an age-dependent skeletal muscle myopathy associated with myofibrillar and intermyofibrillar disorganization in mice.
Domenighetti AA, Chu PH, Wu T, Sheikh F, Gokhin DS, Guo LT, Cui Z, Peter AK, Christodoulou DC, Parfenov MG, Gorham JM, Li DY, Banerjee I, Lai X, Witzmann FA, Seidman CE, Seidman JG, Gomes AV, Shelton GD, Lieber RL, Chen J. Domenighetti AA, et al. Among authors: wu t. Hum Mol Genet. 2014 Jan 1;23(1):209-25. doi: 10.1093/hmg/ddt412. Epub 2013 Aug 23. Hum Mol Genet. 2014. PMID: 23975679 Free PMC article.
Adipocyte-specific loss of PPARγ attenuates cardiac hypertrophy.
Fang X, Stroud MJ, Ouyang K, Fang L, Zhang J, Dalton ND, Gu Y, Wu T, Peterson KL, Huang HD, Chen J, Wang N. Fang X, et al. Among authors: wu t. JCI Insight. 2016 Oct 6;1(16):e89908. doi: 10.1172/jci.insight.89908. JCI Insight. 2016. PMID: 27734035 Free PMC article.
Loss-of-function mutations in co-chaperone BAG3 destabilize small HSPs and cause cardiomyopathy.
Fang X, Bogomolovas J, Wu T, Zhang W, Liu C, Veevers J, Stroud MJ, Zhang Z, Ma X, Mu Y, Lao DH, Dalton ND, Gu Y, Wang C, Wang M, Liang Y, Lange S, Ouyang K, Peterson KL, Evans SM, Chen J. Fang X, et al. Among authors: wu t. J Clin Invest. 2017 Aug 1;127(8):3189-3200. doi: 10.1172/JCI94310. Epub 2017 Jul 24. J Clin Invest. 2017. PMID: 28737513 Free PMC article.
Homozygous G650del nexilin variant causes cardiomyopathy in mice.
Liu C, Spinozzi S, Feng W, Chen Z, Zhang L, Zhu S, Wu T, Fang X, Ouyang K, Evans SM, Chen J. Liu C, et al. Among authors: wu t. JCI Insight. 2020 Aug 20;5(16):e138780. doi: 10.1172/jci.insight.138780. JCI Insight. 2020. PMID: 32814711 Free PMC article.
p38 MAPK reins in right ventricular growth.
Wu T, Chen J. Wu T, et al. J Clin Invest. 2020 Oct 1;130(10):5109-5111. doi: 10.1172/JCI140793. J Clin Invest. 2020. PMID: 32865520 Free PMC article.
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