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Page 1
The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability.
Mirali S, Botham A, Voisin V, Xu C, St-Germain J, Sharon D, Hoff FW, Qiu Y, Hurren R, Gronda M, Jitkova Y, Nachmias B, MacLean N, Wang X, Arruda A, Minden MD, Horton TM, Kornblau SM, Chan SM, Bader GD, Raught B, Schimmer AD. Mirali S, et al. Among authors: botham a. Sci Transl Med. 2020 Apr 8;12(538):eaaz8264. doi: 10.1126/scitranslmed.aaz8264. Sci Transl Med. 2020. PMID: 32269163
IPO11 regulates the nuclear import of BZW1/2 and is necessary for AML cells and stem cells.
Nachmias B, Khan DH, Voisin V, Mer AS, Thomas GE, Segev N, St-Germain J, Hurren R, Gronda M, Botham A, Wang X, Maclean N, Seneviratne AK, Duong N, Xu C, Arruda A, Orouji E, Algouneh A, Hakem R, Shlush L, Minden MD, Raught B, Bader GD, Schimmer AD. Nachmias B, et al. Among authors: botham a. Leukemia. 2022 May;36(5):1283-1295. doi: 10.1038/s41375-022-01513-4. Epub 2022 Feb 12. Leukemia. 2022. PMID: 35152270 Free PMC article.
The metabolic enzyme hexokinase 2 localizes to the nucleus in AML and normal haematopoietic stem and progenitor cells to maintain stemness.
Thomas GE, Egan G, García-Prat L, Botham A, Voisin V, Patel PS, Hoff FW, Chin J, Nachmias B, Kaufmann KB, Khan DH, Hurren R, Wang X, Gronda M, MacLean N, O'Brien C, Singh RP, Jones CL, Harding SM, Raught B, Arruda A, Minden MD, Bader GD, Hakem R, Kornblau S, Dick JE, Schimmer AD. Thomas GE, et al. Among authors: botham a. Nat Cell Biol. 2022 Jun;24(6):872-884. doi: 10.1038/s41556-022-00925-9. Epub 2022 Jun 6. Nat Cell Biol. 2022. PMID: 35668135 Free PMC article.
Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4.
Ramachandran R, Sadofsky LR, Xiao Y, Botham A, Cowen M, Morice AH, Compton SJ. Ramachandran R, et al. Among authors: botham a. Am J Physiol Lung Cell Mol Physiol. 2007 Mar;292(3):L788-98. doi: 10.1152/ajplung.00226.2006. Epub 2006 Dec 1. Am J Physiol Lung Cell Mol Physiol. 2007. PMID: 17142351 Free article.
The molecular cloning and functional expression of the dog CCR5.
Mosley M, Pullen S, Botham A, Gray A, Napier C, Mansfield R, Holbrook M. Mosley M, et al. Among authors: botham a. Vet Immunol Immunopathol. 2006 Oct 15;113(3-4):415-20. doi: 10.1016/j.vetimm.2006.05.009. Epub 2006 Jun 27. Vet Immunol Immunopathol. 2006. PMID: 16806494