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Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model.

Laure M, Hamza H, Koch-Heier J, Quernheim M, Müller C, Schreiber A, Müller G, Pleschka S, Ludwig S, Planz O. Laure M, et al. Among authors: koch heier j. Antiviral Res. 2020 Jun;178:104806. doi: 10.1016/j.antiviral.2020.104806. Epub 2020 Apr 15. Antiviral Res. 2020. PMID: 32304723 Free article.

Pharmacokinetics, Pharmacodynamics and Antiviral Efficacy of the MEK Inhibitor Zapnometinib in Animal Models and in Humans.

Koch-Heier J, Schönsiegel A, Waidele LM, Volk J, Füll Y, Wallasch C, Canisius S, Burnet M, Planz O. Koch-Heier J, et al. Front Pharmacol. 2022 Jun 15;13:893635. doi: 10.3389/fphar.2022.893635. eCollection 2022. Front Pharmacol. 2022. PMID: 35784712 Free PMC article.

Inactivation of SARS-CoV-2 through Treatment with the Mouth Rinsing Solutions ViruProX^® and BacterX^® Pro.

Koch-Heier J, Hoffmann H, Schindler M, Lussi A, Planz O. Koch-Heier J, et al. Microorganisms. 2021 Mar 3;9(3):521. doi: 10.3390/microorganisms9030521. Microorganisms. 2021. PMID: 33802603 Free PMC article.

MEK-inhibitor treatment reduces the induction of regulatory T cells in mice after influenza A virus infection.

Koch-Heier J, Vogel AB, Füll Y, Ebensperger M, Schönsiegel A, Zinser RS, Planz O. Koch-Heier J, et al. Front Immunol. 2024 Jun 24;15:1360698. doi: 10.3389/fimmu.2024.1360698. eCollection 2024. Front Immunol. 2024. PMID: 38979428 Free PMC article.

Influenza A virus replication has a stronger dependency on Raf/MEK/ERK signaling pathway activity than SARS-CoV-2.

Hoffmann H, Ebensperger M, Schönsiegel A, Hamza H, Koch-Heier J, Schreiber A, Ludwig S, Schindler M, Planz O. Hoffmann H, et al. Among authors: koch heier j. Front Cell Infect Microbiol. 2023 Oct 26;13:1264983. doi: 10.3389/fcimb.2023.1264983. eCollection 2023. Front Cell Infect Microbiol. 2023. PMID: 37965261 Free PMC article.

Establishment of a novel method to assess MEK1/2 inhibition in PBMCs for clinical drug development.

Schüssele LM, Koch-Heier J, Volk J, Löffler MW, Hoffmann K, Bruyns RM, Planz O. Schüssele LM, et al. Among authors: koch heier j. Front Cell Dev Biol. 2022 Dec 12;10:1063692. doi: 10.3389/fcell.2022.1063692. eCollection 2022. Front Cell Dev Biol. 2022. PMID: 36578787 Free PMC article.

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