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The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase-leukotriene B4 axis.
Hosooka T, Hosokawa Y, Matsugi K, Shinohara M, Senga Y, Tamori Y, Aoki C, Matsui S, Sasaki T, Kitamura T, Kuroda M, Sakaue H, Nomura K, Yoshino K, Nabatame Y, Itoh Y, Yamaguchi K, Hayashi Y, Nakae J, Accili D, Yokomizo T, Seino S, Kasuga M, Ogawa W. Hosooka T, et al. Among authors: seino s. Proc Natl Acad Sci U S A. 2020 May 26;117(21):11674-11684. doi: 10.1073/pnas.1921015117. Epub 2020 May 11. Proc Natl Acad Sci U S A. 2020. PMID: 32393635 Free PMC article.
Noc2 is essential in normal regulation of exocytosis in endocrine and exocrine cells.
Matsumoto M, Miki T, Shibasaki T, Kawaguchi M, Shinozaki H, Nio J, Saraya A, Koseki H, Miyazaki M, Iwanaga T, Seino S. Matsumoto M, et al. Among authors: seino s. Proc Natl Acad Sci U S A. 2004 Jun 1;101(22):8313-8. doi: 10.1073/pnas.0306709101. Epub 2004 May 24. Proc Natl Acad Sci U S A. 2004. PMID: 15159548 Free PMC article.
Dmbx1 is essential in agouti-related protein action.
Fujimoto W, Shiuchi T, Miki T, Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M, Iwanaga T, Seino S. Fujimoto W, et al. Among authors: seino s. Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15514-9. doi: 10.1073/pnas.0707328104. Epub 2007 Sep 14. Proc Natl Acad Sci U S A. 2007. PMID: 17873059 Free PMC article.
Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP.
Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J, Seino S. Shibasaki T, et al. Among authors: seino s. Proc Natl Acad Sci U S A. 2007 Dec 4;104(49):19333-8. doi: 10.1073/pnas.0707054104. Epub 2007 Nov 26. Proc Natl Acad Sci U S A. 2007. PMID: 18040047 Free PMC article.
Ablation of TSC2 enhances insulin secretion by increasing the number of mitochondria through activation of mTORC1.
Koyanagi M, Asahara S, Matsuda T, Hashimoto N, Shigeyama Y, Shibutani Y, Kanno A, Fuchita M, Mikami T, Hosooka T, Inoue H, Matsumoto M, Koike M, Uchiyama Y, Noda T, Seino S, Kasuga M, Kido Y. Koyanagi M, et al. Among authors: seino s. PLoS One. 2011;6(8):e23238. doi: 10.1371/journal.pone.0023238. Epub 2011 Aug 19. PLoS One. 2011. PMID: 21886784 Free PMC article.
DPP4 inhibitor vildagliptin preserves β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice.
Shimizu S, Hosooka T, Matsuda T, Asahara S, Koyanagi-Kimura M, Kanno A, Bartolome A, Etoh H, Fuchita M, Teruyama K, Takahashi H, Inoue H, Mieda Y, Hashimoto N, Seino S, Kido Y. Shimizu S, et al. Among authors: seino s. J Mol Endocrinol. 2012 Aug 30;49(2):125-35. doi: 10.1530/JME-12-0039. Print 2012 Oct. J Mol Endocrinol. 2012. PMID: 22822047
639 results