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Page 1
Discovery of a NAPE-PLD inhibitor that modulates emotional behavior in mice.
Mock ED, Mustafa M, Gunduz-Cinar O, Cinar R, Petrie GN, Kantae V, Di X, Ogasawara D, Varga ZV, Paloczi J, Miliano C, Donvito G, van Esbroeck ACM, van der Gracht AMF, Kotsogianni I, Park JK, Martella A, van der Wel T, Soethoudt M, Jiang M, Wendel TJ, Janssen APA, Bakker AT, Donovan CM, Castillo LI, Florea BI, Wat J, van den Hurk H, Wittwer M, Grether U, Holmes A, van Boeckel CAA, Hankemeier T, Cravatt BF, Buczynski MW, Hill MN, Pacher P, Lichtman AH, van der Stelt M. Mock ED, et al. Among authors: cinar r. Nat Chem Biol. 2020 Jun;16(6):667-675. doi: 10.1038/s41589-020-0528-7. Epub 2020 May 11. Nat Chem Biol. 2020. PMID: 32393901 Free PMC article.
Inhibitor of fatty acid amide hydrolase normalizes cardiovascular function in hypertension without adverse metabolic effects.
Godlewski G, Alapafuja SO, Bátkai S, Nikas SP, Cinar R, Offertáler L, Osei-Hyiaman D, Liu J, Mukhopadhyay B, Harvey-White J, Tam J, Pacak K, Blankman JL, Cravatt BF, Makriyannis A, Kunos G. Godlewski G, et al. Among authors: cinar r. Chem Biol. 2010 Nov 24;17(11):1256-66. doi: 10.1016/j.chembiol.2010.08.013. Chem Biol. 2010. PMID: 21095576 Free PMC article.
Hyperactivation of anandamide synthesis and regulation of cell-cycle progression via cannabinoid type 1 (CB1) receptors in the regenerating liver.
Mukhopadhyay B, Cinar R, Yin S, Liu J, Tam J, Godlewski G, Harvey-White J, Mordi I, Cravatt BF, Lotersztajn S, Gao B, Yuan Q, Schuebel K, Goldman D, Kunos G. Mukhopadhyay B, et al. Among authors: cinar r. Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6323-8. doi: 10.1073/pnas.1017689108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383171 Free PMC article.
Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity.
Gunduz-Cinar O, MacPherson KP, Cinar R, Gamble-George J, Sugden K, Williams B, Godlewski G, Ramikie TS, Gorka AX, Alapafuja SO, Nikas SP, Makriyannis A, Poulton R, Patel S, Hariri AR, Caspi A, Moffitt TE, Kunos G, Holmes A. Gunduz-Cinar O, et al. Among authors: cinar r. Mol Psychiatry. 2013 Jul;18(7):813-23. doi: 10.1038/mp.2012.72. Epub 2012 Jun 12. Mol Psychiatry. 2013. PMID: 22688188 Free PMC article.
Chronic alcohol produces neuroadaptations to prime dorsal striatal learning.
DePoy L, Daut R, Brigman JL, MacPherson K, Crowley N, Gunduz-Cinar O, Pickens CL, Cinar R, Saksida LM, Kunos G, Lovinger DM, Bussey TJ, Camp MC, Holmes A. DePoy L, et al. Among authors: cinar r. Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14783-8. doi: 10.1073/pnas.1308198110. Epub 2013 Aug 19. Proc Natl Acad Sci U S A. 2013. PMID: 23959891 Free PMC article.
Overactive cannabinoid 1 receptor in podocytes drives type 2 diabetic nephropathy.
Jourdan T, Szanda G, Rosenberg AZ, Tam J, Earley BJ, Godlewski G, Cinar R, Liu Z, Liu J, Ju C, Pacher P, Kunos G. Jourdan T, et al. Among authors: cinar r. Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5420-8. doi: 10.1073/pnas.1419901111. Epub 2014 Nov 24. Proc Natl Acad Sci U S A. 2014. PMID: 25422468 Free PMC article.
The novel, orally available and peripherally restricted selective cannabinoid CB2 receptor agonist LEI-101 prevents cisplatin-induced nephrotoxicity.
Mukhopadhyay P, Baggelaar M, Erdelyi K, Cao Z, Cinar R, Fezza F, Ignatowska-Janlowska B, Wilkerson J, van Gils N, Hansen T, Ruben M, Soethoudt M, Heitman L, Kunos G, Maccarrone M, Lichtman A, Pacher P, Van der Stelt M. Mukhopadhyay P, et al. Among authors: cinar r. Br J Pharmacol. 2016 Feb;173(3):446-58. doi: 10.1111/bph.13338. Epub 2016 Jan 15. Br J Pharmacol. 2016. PMID: 26398481 Free PMC article.
Fluoxetine Facilitates Fear Extinction Through Amygdala Endocannabinoids.
Gunduz-Cinar O, Flynn S, Brockway E, Kaugars K, Baldi R, Ramikie TS, Cinar R, Kunos G, Patel S, Holmes A. Gunduz-Cinar O, et al. Among authors: cinar r. Neuropsychopharmacology. 2016 May;41(6):1598-609. doi: 10.1038/npp.2015.318. Epub 2015 Oct 30. Neuropsychopharmacology. 2016. PMID: 26514583 Free PMC article.
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