Chen L - Search Results

1

Discovery of Targeted Covalent Natural Products against PLK1 by Herb-Based Screening.

Liang H, Liu H, Kuang Y, Chen L, Ye M, Lai L. Liang H, et al. Among authors: chen l. J Chem Inf Model. 2020 Sep 28;60(9):4350-4358. doi: 10.1021/acs.jcim.0c00074. Epub 2020 May 28. J Chem Inf Model. 2020. PMID: 32407091

2

Computational strategy for intrinsically disordered protein ligand design leads to the discovery of p53 transactivation domain I binding compounds that activate the p53 pathway.

Ruan H, Yu C, Niu X, Zhang W, Liu H, Chen L, Xiong R, Sun Q, Jin C, Liu Y, Lai L. Ruan H, et al. Among authors: chen l. Chem Sci. 2020 Dec 28;12(8):3004-3016. doi: 10.1039/d0sc04670a. Chem Sci. 2020. PMID: 34164069 Free PMC article.

3

Ligand-based optimization and biological evaluation of N-(2,2,2-trichloro-1-(3-phenylthioureido)ethyl)acetamide derivatives as potent intrinsically disordered protein c-Myc inhibitors.

Chen L, Cheng B, Sun Q, Lai L. Chen L, et al. Bioorg Med Chem Lett. 2021 Jan 1;31:127711. doi: 10.1016/j.bmcl.2020.127711. Epub 2020 Nov 24. Bioorg Med Chem Lett. 2021. PMID: 33246106

4

Discovering potent inhibitors against c-Met kinase: molecular design, organic synthesis and bioassay.

Liang Z, Ding X, Ai J, Kong X, Chen L, Chen L, Luo C, Geng M, Liu H, Chen K, Jiang H. Liang Z, et al. Among authors: chen k, chen l. Org Biomol Chem. 2012 Jan 14;10(2):421-30. doi: 10.1039/c1ob06186k. Epub 2011 Nov 23. Org Biomol Chem. 2012. PMID: 22108637

5

Discovery of novel BRD4 inhibitors by high-throughput screening, crystallography, and cell-based assays.

Sun Z, Zhang H, Chen Z, Xie Y, Jiang H, Chen L, Ding H, Zhang Y, Jiang H, Zheng M, Luo C. Sun Z, et al. Among authors: chen z, chen l. Bioorg Med Chem Lett. 2017 May 1;27(9):2003-2009. doi: 10.1016/j.bmcl.2017.03.012. Epub 2017 Mar 9. Bioorg Med Chem Lett. 2017. PMID: 28347667

6

Identification of novel EZH2 inhibitors through pharmacophore-based virtual screening and biological assays.

Wu Y, Hu J, Ding H, Chen L, Zhang Y, Liu R, Xu P, Du D, Lu W, Liu J, Liu Y, Liu YC, Lu J, Zhang J, Yao Z, Luo C. Wu Y, et al. Among authors: chen l. Bioorg Med Chem Lett. 2016 Aug 1;26(15):3813-7. doi: 10.1016/j.bmcl.2016.05.018. Epub 2016 May 30. Bioorg Med Chem Lett. 2016. PMID: 27289323

7

Pharmacophore-based virtual screening and biological evaluation of small molecule inhibitors for protein arginine methylation.

Wang J, Chen L, Sinha SH, Liang Z, Chai H, Muniyan S, Chou YW, Yang C, Yan L, Feng Y, Li KK, Lin MF, Jiang H, Zheng YG, Luo C. Wang J, et al. Among authors: chen l. J Med Chem. 2012 Sep 27;55(18):7978-87. doi: 10.1021/jm300521m. Epub 2012 Sep 12. J Med Chem. 2012. PMID: 22928876 Free PMC article.

8

Identification and synthesis of N'-(2-oxoindolin-3-ylidene)hydrazide derivatives against c-Met kinase.

Liang Z, Zhang D, Ai J, Chen L, Wang H, Kong X, Zheng M, Liu H, Luo C, Geng M, Jiang H, Chen K. Liang Z, et al. Among authors: chen k, chen l. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3749-54. doi: 10.1016/j.bmcl.2011.04.064. Epub 2011 Apr 22. Bioorg Med Chem Lett. 2011. PMID: 21561768

9

Promotion of In Vitro Chondrogenesis of Mesenchymal Stem Cells Using In Situ Hyaluronic Hydrogel Functionalized with Rod-Like Viral Nanoparticles.

Maturavongsadit P, Luckanagul JA, Metavarayuth K, Zhao X, Chen L, Lin Y, Wang Q. Maturavongsadit P, et al. Among authors: chen l. Biomacromolecules. 2016 Jun 13;17(6):1930-8. doi: 10.1021/acs.biomac.5b01577. Epub 2016 Apr 1. Biomacromolecules. 2016. PMID: 26999064

10

Network modelling reveals the mechanism underlying colitis-associated colon cancer and identifies novel combinatorial anti-cancer targets.

Lu J, Zeng H, Liang Z, Chen L, Zhang L, Zhang H, Liu H, Jiang H, Shen B, Huang M, Geng M, Spiegel S, Luo C. Lu J, et al. Among authors: chen l. Sci Rep. 2015 Oct 8;5:14739. doi: 10.1038/srep14739. Sci Rep. 2015. PMID: 26446703 Free PMC article.

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