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De novo protein design enables the precise induction of RSV-neutralizing antibodies.
Sesterhenn F, Yang C, Bonet J, Cramer JT, Wen X, Wang Y, Chiang CI, Abriata LA, Kucharska I, Castoro G, Vollers SS, Galloux M, Dheilly E, Rosset S, Corthésy P, Georgeon S, Villard M, Richard CA, Descamps D, Delgado T, Oricchio E, Rameix-Welti MA, Más V, Ervin S, Eléouët JF, Riffault S, Bates JT, Julien JP, Li Y, Jardetzky T, Krey T, Correia BE. Sesterhenn F, et al. Among authors: yang c. Science. 2020 May 15;368(6492):eaay5051. doi: 10.1126/science.aay5051. Science. 2020. PMID: 32409444 Free PMC article.
Rosetta FunFolDes - A general framework for the computational design of functional proteins.
Bonet J, Wehrle S, Schriever K, Yang C, Billet A, Sesterhenn F, Scheck A, Sverrisson F, Veselkova B, Vollers S, Lourman R, Villard M, Rosset S, Krey T, Correia BE. Bonet J, et al. Among authors: yang c. PLoS Comput Biol. 2018 Nov 19;14(11):e1006623. doi: 10.1371/journal.pcbi.1006623. eCollection 2018 Nov. PLoS Comput Biol. 2018. PMID: 30452434 Free PMC article.
Boosting subdominant neutralizing antibody responses with a computationally designed epitope-focused immunogen.
Sesterhenn F, Galloux M, Vollers SS, Csepregi L, Yang C, Descamps D, Bonet J, Friedensohn S, Gainza P, Corthésy P, Chen M, Rosset S, Rameix-Welti MA, Éléouët JF, Reddy ST, Graham BS, Riffault S, Correia BE. Sesterhenn F, et al. Among authors: yang c. PLoS Biol. 2019 Feb 21;17(2):e3000164. doi: 10.1371/journal.pbio.3000164. eCollection 2019 Feb. PLoS Biol. 2019. PMID: 30789898 Free PMC article.
Bottom-up de novo design of functional proteins with complex structural features.
Yang C, Sesterhenn F, Bonet J, van Aalen EA, Scheller L, Abriata LA, Cramer JT, Wen X, Rosset S, Georgeon S, Jardetzky T, Krey T, Fussenegger M, Merkx M, Correia BE. Yang C, et al. Nat Chem Biol. 2021 Apr;17(4):492-500. doi: 10.1038/s41589-020-00699-x. Epub 2021 Jan 4. Nat Chem Biol. 2021. PMID: 33398169
A generic framework for hierarchical de novo protein design.
Harteveld Z, Bonet J, Rosset S, Yang C, Sesterhenn F, Correia BE. Harteveld Z, et al. Among authors: yang c. Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2206111119. doi: 10.1073/pnas.2206111119. Epub 2022 Oct 17. Proc Natl Acad Sci U S A. 2022. PMID: 36252041 Free PMC article.
Assessing and enhancing foldability in designed proteins.
Listov D, Lipsh-Sokolik R, Rosset S, Yang C, Correia BE, Fleishman SJ. Listov D, et al. Among authors: yang c. Protein Sci. 2022 Sep;31(9):e4400. doi: 10.1002/pro.4400. Protein Sci. 2022. PMID: 36040259 Free PMC article.
A rational blueprint for the design of chemically-controlled protein switches.
Shui S, Gainza P, Scheller L, Yang C, Kurumida Y, Rosset S, Georgeon S, Di Roberto RB, Castellanos-Rueda R, Reddy ST, Correia BE. Shui S, et al. Among authors: yang c. Nat Commun. 2021 Oct 1;12(1):5754. doi: 10.1038/s41467-021-25735-9. Nat Commun. 2021. PMID: 34599176 Free PMC article.
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