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The type 2 diabetes gene product STARD10 is a phosphoinositide-binding protein that controls insulin secretory granule biogenesis.
Carrat GR, Haythorne E, Tomas A, Haataja L, Müller A, Arvan P, Piunti A, Cheng K, Huang M, Pullen TJ, Georgiadou E, Stylianides T, Amirruddin NS, Salem V, Distaso W, Cakebread A, Heesom KJ, Lewis PA, Hodson DJ, Briant LJ, Fung ACH, Sessions RB, Alpy F, Kong APS, Benke PI, Torta F, Teo AKK, Leclerc I, Solimena M, Wigley DB, Rutter GA. Carrat GR, et al. Among authors: hodson dj. Mol Metab. 2020 Oct;40:101015. doi: 10.1016/j.molmet.2020.101015. Epub 2020 May 13. Mol Metab. 2020. PMID: 32416313 Free PMC article.
ADCY5 couples glucose to insulin secretion in human islets.
Hodson DJ, Mitchell RK, Marselli L, Pullen TJ, Gimeno Brias S, Semplici F, Everett KL, Cooper DM, Bugliani M, Marchetti P, Lavallard V, Bosco D, Piemonti L, Johnson PR, Hughes SJ, Li D, Li WH, Shapiro AM, Rutter GA. Hodson DJ, et al. Diabetes. 2014 Sep;63(9):3009-21. doi: 10.2337/db13-1607. Epub 2014 Apr 16. Diabetes. 2014. PMID: 24740569 Free PMC article.
Incretin-modulated beta cell energetics in intact islets of Langerhans.
Hodson DJ, Tarasov AI, Gimeno Brias S, Mitchell RK, Johnston NR, Haghollahi S, Cane MC, Bugliani M, Marchetti P, Bosco D, Johnson PR, Hughes SJ, Rutter GA. Hodson DJ, et al. Mol Endocrinol. 2014 Jun;28(6):860-71. doi: 10.1210/me.2014-1038. Epub 2014 Apr 25. Mol Endocrinol. 2014. PMID: 24766140 Free PMC article.
Hypoxia lowers SLC30A8/ZnT8 expression and free cytosolic Zn2+ in pancreatic beta cells.
Gerber PA, Bellomo EA, Hodson DJ, Meur G, Solomou A, Mitchell RK, Hollinshead M, Chimienti F, Bosco D, Hughes SJ, Johnson PR, Rutter GA. Gerber PA, et al. Among authors: hodson dj. Diabetologia. 2014 Aug;57(8):1635-44. doi: 10.1007/s00125-014-3266-0. Epub 2014 May 28. Diabetologia. 2014. PMID: 24865615 Free PMC article.
Optical control of insulin release using a photoswitchable sulfonylurea.
Broichhagen J, Schönberger M, Cork SC, Frank JA, Marchetti P, Bugliani M, Shapiro AM, Trapp S, Rutter GA, Hodson DJ, Trauner D. Broichhagen J, et al. Among authors: hodson dj. Nat Commun. 2014 Oct 14;5:5116. doi: 10.1038/ncomms6116. Nat Commun. 2014. PMID: 25311795 Free PMC article.
Rfx6 maintains the functional identity of adult pancreatic β cells.
Piccand J, Strasser P, Hodson DJ, Meunier A, Ye T, Keime C, Birling MC, Rutter GA, Gradwohl G. Piccand J, et al. Among authors: hodson dj. Cell Rep. 2014 Dec 24;9(6):2219-32. doi: 10.1016/j.celrep.2014.11.033. Epub 2014 Dec 11. Cell Rep. 2014. PMID: 25497096 Free PMC article.
Biologically targeted probes for Zn2+: a diversity oriented modular "click-SNAr-click" approach†Electronic supplementary information (ESI) available: Full experimental details including characterisation of all novel compounds can be found in the ESI. See DOI: 10.1039/c4sc01249f.
Pancholi J, Hodson DJ, Jobe K, Rutter GA, Goldup SM, Watkinson M. Pancholi J, et al. Among authors: hodson dj. Chem Sci. 2014 Sep 28;5(9):3528-3535. doi: 10.1039/c4sc01249f. Epub 2014 Jun 27. Chem Sci. 2014. PMID: 25580213 Free PMC article.
182 results