Uitdehaag JCM - Search Results

1

High-Throughput Fluorescence-Based Activity Assay for Arginase-1.

Grobben Y, Willemsen-Seegers N, Uitdehaag JCM, de Man J, van Groningen J, Friesen J, van den Hurk H, Buijsman RC, Zaman GJR. Grobben Y, et al. Among authors: uitdehaag jcm. SLAS Discov. 2020 Oct;25(9):1018-1025. doi: 10.1177/2472555220919340. Epub 2020 May 16. SLAS Discov. 2020. PMID: 32418491 Free article.

2

High-throughput fluorescence-based screening assays for tryptophan-catabolizing enzymes.

Seegers N, van Doornmalen AM, Uitdehaag JC, de Man J, Buijsman RC, Zaman GJ. Seegers N, et al. J Biomol Screen. 2014 Oct;19(9):1266-74. doi: 10.1177/1087057114536616. Epub 2014 May 27. J Biomol Screen. 2014. PMID: 24870017

3

A theoretical entropy score as a single value to express inhibitor selectivity.

Uitdehaag JC, Zaman GJ. Uitdehaag JC, et al. BMC Bioinformatics. 2011 Apr 12;12:94. doi: 10.1186/1471-2105-12-94. BMC Bioinformatics. 2011. PMID: 21486481 Free PMC article.

4

Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use.

Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, de Man J, Tanizawa Y, Kawase Y, Yoshino K, Buijsman RC, Zaman GJ. Uitdehaag JC, et al. PLoS One. 2014 Mar 20;9(3):e92146. doi: 10.1371/journal.pone.0092146. eCollection 2014. PLoS One. 2014. PMID: 24651269 Free PMC article.

5

Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.

Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, Spijkers-Hagelstein JA, de Vetter JR, de Man J, Buijsman RC, Zaman GJ. Uitdehaag JC, et al. PLoS One. 2015 May 27;10(5):e0125021. doi: 10.1371/journal.pone.0125021. eCollection 2015. PLoS One. 2015. PMID: 26018524 Free PMC article.

6

Stable aneuploid tumors cells are more sensitive to TTK inhibition than chromosomally unstable cell lines.

Libouban MAA, de Roos JADM, Uitdehaag JCM, Willemsen-Seegers N, Mainardi S, Dylus J, de Man J, Tops B, Meijerink JPP, Storchová Z, Buijsman RC, Medema RH, Zaman GJR. Libouban MAA, et al. Among authors: uitdehaag jcm. Oncotarget. 2017 Jun 13;8(24):38309-38325. doi: 10.18632/oncotarget.16213. Oncotarget. 2017. PMID: 28415765 Free PMC article.

7

Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.

Uitdehaag JCM, de Man J, Willemsen-Seegers N, Prinsen MBW, Libouban MAA, Sterrenburg JG, de Wit JJP, de Vetter JRF, de Roos JADM, Buijsman RC, Zaman GJR. Uitdehaag JCM, et al. J Mol Biol. 2017 Jul 7;429(14):2211-2230. doi: 10.1016/j.jmb.2017.05.014. Epub 2017 May 21. J Mol Biol. 2017. PMID: 28539250

8

TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers.

Zaman GJR, de Roos JADM, Libouban MAA, Prinsen MBW, de Man J, Buijsman RC, Uitdehaag JCM. Zaman GJR, et al. Among authors: uitdehaag jcm. Mol Cancer Ther. 2017 Nov;16(11):2609-2617. doi: 10.1158/1535-7163.MCT-17-0342. Epub 2017 Jul 27. Mol Cancer Ther. 2017. PMID: 28751540

9

Structural insights into human Arginase-1 pH dependence and its inhibition by the small molecule inhibitor CB-1158.

Grobben Y, Uitdehaag JCM, Willemsen-Seegers N, Tabak WWA, de Man J, Buijsman RC, Zaman GJR. Grobben Y, et al. Among authors: uitdehaag jcm. J Struct Biol X. 2019 Nov 26;4:100014. doi: 10.1016/j.yjsbx.2019.100014. eCollection 2020. J Struct Biol X. 2019. PMID: 32647818 Free PMC article.

10

Pharmacological validation of TDO as a target for Parkinson's disease.

Perez-Pardo P, Grobben Y, Willemsen-Seegers N, Hartog M, Tutone M, Muller M, Adolfs Y, Pasterkamp RJ, Vu-Pham D, van Doornmalen AM, van Cauter F, de Wit J, Gerard Sterrenburg J, Uitdehaag JCM, de Man J, Buijsman RC, Zaman GJR, Kraneveld AD. Perez-Pardo P, et al. Among authors: uitdehaag jcm. FEBS J. 2021 Jul;288(14):4311-4331. doi: 10.1111/febs.15721. Epub 2021 Feb 18. FEBS J. 2021. PMID: 33471408 Free PMC article.

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