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Therapies for tuberculosis and AIDS: myeloid-derived suppressor cells in focus.
Dorhoi A, Kotzé LA, Berzofsky JA, Sui Y, Gabrilovich DI, Garg A, Hafner R, Khader SA, Schaible UE, Kaufmann SH, Walzl G, Lutz MB, Mahon RN, Ostrand-Rosenberg S, Bishai W, du Plessis N. Dorhoi A, et al. Among authors: khader sa. J Clin Invest. 2020 Jun 1;130(6):2789-2799. doi: 10.1172/JCI136288. J Clin Invest. 2020. PMID: 32420917 Free PMC article. Review.
CXCR5⁺ T helper cells mediate protective immunity against tuberculosis.
Slight SR, Rangel-Moreno J, Gopal R, Lin Y, Fallert Junecko BA, Mehra S, Selman M, Becerril-Villanueva E, Baquera-Heredia J, Pavon L, Kaushal D, Reinhart TA, Randall TD, Khader SA. Slight SR, et al. Among authors: khader sa. J Clin Invest. 2013 Feb;123(2):712-26. doi: 10.1172/JCI65728. Epub 2013 Jan 2. J Clin Invest. 2013. PMID: 23281399 Free PMC article.
Targeting innate immunity for tuberculosis vaccination.
Khader SA, Divangahi M, Hanekom W, Hill PC, Maeurer M, Makar KW, Mayer-Barber KD, Mhlanga MM, Nemes E, Schlesinger LS, van Crevel R, Vankayalapati R(, Xavier RJ, Netea MG; Bill and Melinda Gates Foundation Collaboration for TB Vaccine Discovery Innate Immunity Working Group18. Khader SA, et al. J Clin Invest. 2019 Sep 3;129(9):3482-3491. doi: 10.1172/JCI128877. J Clin Invest. 2019. PMID: 31478909 Free PMC article. Review.
Mechanisms of reactivation of latent tuberculosis infection due to SIV coinfection.
Bucşan AN, Chatterjee A, Singh DK, Foreman TW, Lee TH, Threeton B, Kirkpatrick MG, Ahmed M, Golden N, Alvarez X, Hoxie JA, Mehra S, Rengarajan J, Khader SA, Kaushal D. Bucşan AN, et al. Among authors: khader sa. J Clin Invest. 2019 Dec 2;129(12):5254-5260. doi: 10.1172/JCI125810. J Clin Invest. 2019. PMID: 31479428 Free PMC article.
S100A8/A9 regulates CD11b expression and neutrophil recruitment during chronic tuberculosis.
Scott NR, Swanson RV, Al-Hammadi N, Domingo-Gonzalez R, Rangel-Moreno J, Kriel BA, Bucsan AN, Das S, Ahmed M, Mehra S, Treerat P, Cruz-Lagunas A, Jimenez-Alvarez L, Muñoz-Torrico M, Bobadilla-Lozoya K, Vogl T, Walzl G, du Plessis N, Kaushal D, Scriba TJ, Zúñiga J, Khader SA. Scott NR, et al. Among authors: khader sa. J Clin Invest. 2020 Jun 1;130(6):3098-3112. doi: 10.1172/JCI130546. J Clin Invest. 2020. PMID: 32134742 Free PMC article.
Antiretroviral therapy does not reduce tuberculosis reactivation in a tuberculosis-HIV coinfection model.
Ganatra SR, Bucşan AN, Alvarez X, Kumar S, Chatterjee A, Quezada M, Fish A, Singh DK, Singh B, Sharan R, Lee TH, Shanmugasundaram U, Velu V, Khader SA, Mehra S, Rengarajan J, Kaushal D. Ganatra SR, et al. Among authors: khader sa. J Clin Invest. 2020 Oct 1;130(10):5171-5179. doi: 10.1172/JCI136502. J Clin Invest. 2020. PMID: 32544085 Free PMC article.
Monocyte progenitors give rise to multinucleated giant cells.
Lösslein AK, Lohrmann F, Scheuermann L, Gharun K, Neuber J, Kolter J, Forde AJ, Kleimeyer C, Poh YY, Mack M, Triantafyllopoulou A, Dunlap MD, Khader SA, Seidl M, Hölscher A, Hölscher C, Guan XL, Dorhoi A, Henneke P. Lösslein AK, et al. Among authors: khader sa. Nat Commun. 2021 Apr 1;12(1):2027. doi: 10.1038/s41467-021-22103-5. Nat Commun. 2021. PMID: 33795674 Free PMC article.
Longitudinal Dynamics of a Blood Transcriptomic Signature of Tuberculosis.
Mulenga H, Musvosvi M, Mendelsohn SC, Penn-Nicholson A, Kimbung Mbandi S, Fiore-Gartland A, Tameris M, Mabwe S, Africa H, Bilek N, Kafaar F, Khader SA, Carstens B, Hadley K, Hikuam C, Erasmus M, Jaxa L, Raphela R, Nombida O, Kaskar M, Nicol MP, Mbhele S, Van Heerden J, Innes C, Brumskine W, Hiemstra A, Malherbe ST, Hassan-Moosa R, Walzl G, Naidoo K, Churchyard G, Hatherill M, Scriba TJ; CORTIS Study Team. Mulenga H, et al. Among authors: khader sa. Am J Respir Crit Care Med. 2021 Dec 15;204(12):1463-1472. doi: 10.1164/rccm.202103-0548OC. Am J Respir Crit Care Med. 2021. PMID: 34520313 Free PMC article.
Antiretroviral therapy timing impacts latent tuberculosis infection reactivation in a Mycobacterium tuberculosis/SIV coinfection model.
Sharan R, Ganatra SR, Bucsan AN, Cole J, Singh DK, Alvarez X, Gough M, Alvarez C, Blakley A, Ferdin J, Thippeshappa R, Singh B, Escobedo R, Shivanna V, Dick EJ Jr, Hall-Ursone S, Khader SA, Mehra S, Rengarajan J, Kaushal D. Sharan R, et al. Among authors: khader sa. J Clin Invest. 2022 Feb 1;132(3):e153090. doi: 10.1172/JCI153090. J Clin Invest. 2022. PMID: 34855621 Free PMC article.
160 results