Largent-Milnes TM - Search Results

1

Chronic Morphine-Induced Changes in Signaling at the A₃ Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal.

Doyle TM, Largent-Milnes TM, Chen Z, Staikopoulos V, Esposito E, Dalgarno R, Fan C, Tosh DK, Cuzzocrea S, Jacobson KA, Trang T, Hutchinson MR, Bennett GJ, Vanderah TW, Salvemini D. Doyle TM, et al. J Pharmacol Exp Ther. 2020 Aug;374(2):331-341. doi: 10.1124/jpet.120.000004. Epub 2020 May 20. J Pharmacol Exp Ther. 2020. PMID: 32434943 Free PMC article.

2

Oxycodone plus ultra-low-dose naltrexone attenuates neuropathic pain and associated mu-opioid receptor-Gs coupling.

Largent-Milnes TM, Guo W, Wang HY, Burns LH, Vanderah TW. Largent-Milnes TM, et al. J Pain. 2008 Aug;9(8):700-13. doi: 10.1016/j.jpain.2008.03.005. Epub 2008 May 12. J Pain. 2008. PMID: 18468954 Free PMC article.

3

A cannabinoid 2 receptor agonist attenuates bone cancer-induced pain and bone loss.

Lozano-Ondoua AN, Wright C, Vardanyan A, King T, Largent-Milnes TM, Nelson M, Jimenez-Andrade JM, Mantyh PW, Vanderah TW. Lozano-Ondoua AN, et al. Life Sci. 2010 Apr 24;86(17-18):646-53. doi: 10.1016/j.lfs.2010.02.014. Epub 2010 Feb 20. Life Sci. 2010. PMID: 20176037 Free PMC article.

4

Recently patented and promising ORL-1 ligands: where have we been and where are we going?

Largent-Milnes TM, Vanderah TW. Largent-Milnes TM, et al. Expert Opin Ther Pat. 2010 Mar;20(3):291-305. doi: 10.1517/13543771003602004. Expert Opin Ther Pat. 2010. PMID: 20180617 Review.

5

Sustained morphine-mediated pain sensitization and antinociceptive tolerance are blocked by intrathecal treatment with Raf-1-selective siRNA.

Tumati S, Roeske WR, Largent-Milnes T, Wang R, Vanderah TW, Varga EV. Tumati S, et al. Br J Pharmacol. 2010 Sep;161(1):51-64. doi: 10.1111/j.1476-5381.2010.00869.x. Br J Pharmacol. 2010. PMID: 20718739 Free PMC article.

6

Spinal or systemic TY005, a peptidic opioid agonist/neurokinin 1 antagonist, attenuates pain with reduced tolerance.

Largent-Milnes TM, Yamamoto T, Nair P, Moulton JW, Hruby VJ, Lai J, Porreca F, Vanderah TW. Largent-Milnes TM, et al. Br J Pharmacol. 2010 Nov;161(5):986-1001. doi: 10.1111/j.1476-5381.2010.00824.x. Br J Pharmacol. 2010. PMID: 20977451 Free PMC article.

7

Discovery of a potent and efficacious peptide derivative for δ/μ opioid agonist/neurokinin 1 antagonist activity with a 2',6'-dimethyl-L-tyrosine: in vitro, in vivo, and NMR-based structural studies.

Yamamoto T, Nair P, Largent-Milnes TM, Jacobsen NE, Davis P, Ma SW, Yamamura HI, Vanderah TW, Porreca F, Lai J, Hruby VJ. Yamamoto T, et al. J Med Chem. 2011 Apr 14;54(7):2029-38. doi: 10.1021/jm101023r. Epub 2011 Mar 2. J Med Chem. 2011. PMID: 21366266 Free PMC article.

8

Novel peptide ligands with dual acting pharmacophores designed for the pathophysiology of neuropathic pain.

Hanlon KE, Herman DS, Agnes RS, Largent-Milnes TM, Kumarasinghe IR, Ma SW, Guo W, Lee YS, Ossipov MH, Hruby VJ, Lai J, Porreca F, Vanderah TW. Hanlon KE, et al. Brain Res. 2011 Jun 13;1395:1-11. doi: 10.1016/j.brainres.2011.04.024. Epub 2011 Apr 20. Brain Res. 2011. PMID: 21550594 Free PMC article.

9

Intrathecal PKA-selective siRNA treatment blocks sustained morphine-mediated pain sensitization and antinociceptive tolerance in rats.

Tumati S, Roeske WR, Largent-Milnes TM, Vanderah TW, Varga EV. Tumati S, et al. J Neurosci Methods. 2011 Jul 15;199(1):62-8. doi: 10.1016/j.jneumeth.2011.04.036. Epub 2011 May 6. J Neurosci Methods. 2011. PMID: 21571003 Free PMC article.

10

Activation of descending pain-facilitatory pathways from the rostral ventromedial medulla by cholecystokinin elicits release of prostaglandin-E₂ in the spinal cord.

Marshall TM, Herman DS, Largent-Milnes TM, Badghisi H, Zuber K, Holt SC, Lai J, Porreca F, Vanderah TW. Marshall TM, et al. Pain. 2012 Jan;153(1):86-94. doi: 10.1016/j.pain.2011.09.021. Epub 2011 Oct 24. Pain. 2012. PMID: 22030324 Free PMC article.

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