Wiebe S - Search Results

1

A Comprehensive Whole-Body Physiologically Based Pharmacokinetic Drug-Drug-Gene Interaction Model of Metformin and Cimetidine in Healthy Adults and Renally Impaired Individuals.

Hanke N, Türk D, Selzer D, Ishiguro N, Ebner T, Wiebe S, Müller F, Stopfer P, Nock V, Lehr T. Hanke N, et al. Among authors: wiebe s. Clin Pharmacokinet. 2020 Nov;59(11):1419-1431. doi: 10.1007/s40262-020-00896-w. Clin Pharmacokinet. 2020. PMID: 32449077 Free PMC article.

2

Influence of Renal Impairment on the Pharmacokinetics of Afatinib: An Open-Label, Single-Dose Study.

Wiebe S, Schnell D, Külzer R, Gansser D, Weber A, Wallenstein G, Halabi A, Conrad A, Wind S. Wiebe S, et al. Eur J Drug Metab Pharmacokinet. 2017 Jun;42(3):461-469. doi: 10.1007/s13318-016-0359-9. Eur J Drug Metab Pharmacokinet. 2017. PMID: 27436099 Free PMC article.

3

Validation of a Drug Transporter Probe Cocktail Using the Prototypical Inhibitors Rifampin, Probenecid, Verapamil, and Cimetidine.

Wiebe ST, Giessmann T, Hohl K, Schmidt-Gerets S, Hauel E, Jambrecina A, Bader K, Ishiguro N, Taub ME, Sharma A, Ebner T, Mikus G, Fromm MF, Müller F, Stopfer P. Wiebe ST, et al. Clin Pharmacokinet. 2020 Dec;59(12):1627-1639. doi: 10.1007/s40262-020-00907-w. Clin Pharmacokinet. 2020. PMID: 32504272 Free PMC article. Clinical Trial.

4

A Mechanistic, Enantioselective, Physiologically Based Pharmacokinetic Model of Verapamil and Norverapamil, Built and Evaluated for Drug-Drug Interaction Studies.

Hanke N, Türk D, Selzer D, Wiebe S, Fernandez É, Stopfer P, Nock V, Lehr T. Hanke N, et al. Among authors: wiebe s. Pharmaceutics. 2020 Jun 16;12(6):556. doi: 10.3390/pharmaceutics12060556. Pharmaceutics. 2020. PMID: 32560124 Free PMC article.

5

Composite midazolam and 1'-OH midazolam population pharmacokinetic model for constitutive, inhibited and induced CYP3A activity.

Wiebe ST, Meid AD, Mikus G. Wiebe ST, et al. J Pharmacokinet Pharmacodyn. 2020 Dec;47(6):527-542. doi: 10.1007/s10928-020-09704-1. Epub 2020 Aug 8. J Pharmacokinet Pharmacodyn. 2020. PMID: 32772302 Free PMC article.

6

Safety, pharmacokinetics and pharmacodynamics of BI 705564, a highly selective, covalent inhibitor of Bruton's tyrosine kinase, in Phase I clinical trials in healthy volunteers.

Litzenburger T, Steffgen J, Benediktus E, Müller F, Schultz A, Klein E, Ramanujam M, Harcken C, Gupta A, Wu J, Wiebe S, Li X, Flack M, Padula SJ, Visvanathan S, Hünnemeyer A, Hui J. Litzenburger T, et al. Among authors: wiebe s. Br J Clin Pharmacol. 2021 Apr;87(4):1824-1838. doi: 10.1111/bcp.14571. Epub 2020 Nov 20. Br J Clin Pharmacol. 2021. PMID: 32986868 Free PMC article. Clinical Trial.

7

No relevant pharmacokinetic drug-drug interaction between nintedanib and pirfenidone.

Richeldi L, Fletcher S, Adamali H, Chaudhuri N, Wiebe S, Wind S, Hohl K, Baker A, Schlenker-Herceg R, Stowasser S, Maher TM. Richeldi L, et al. Among authors: wiebe s. Eur Respir J. 2019 Jan 10;53(1):1801060. doi: 10.1183/13993003.01060-2018. Print 2019 Jan. Eur Respir J. 2019. PMID: 30442716 Free article. Clinical Trial.

8

Midazolam microdosing applied in early clinical development for drug-drug interaction assessment.

Wiebe ST, Huennemeyer A, Kadus W, Goettel M, Jambrecina A, Schultz A, Vinisko R, Schlieker L, Herich L, Mikus G. Wiebe ST, et al. Br J Clin Pharmacol. 2021 Jan;87(1):178-188. doi: 10.1111/bcp.14389. Epub 2020 Jun 10. Br J Clin Pharmacol. 2021. PMID: 32436239 Free article.

9

Pharmacokinetics/Pharmacodynamics of Dabigatran 75 mg Twice Daily in Patients With Nonvalvular Atrial Fibrillation and Severely Impaired Renal Function.

Martin JL, Esmaeili H, Manuel RC, Petrini M, Wiebe S, Maas H. Martin JL, et al. Among authors: wiebe s. J Cardiovasc Pharmacol Ther. 2018 Sep;23(5):399-406. doi: 10.1177/1074248418769167. Epub 2018 Apr 25. J Cardiovasc Pharmacol Ther. 2018. PMID: 29695165 Clinical Trial.

10

Effects of Single and Multiple Ascending Doses of BI 1358894 in Healthy Male Volunteers on Safety, Tolerability and Pharmacokinetics: Two Phase I Partially Randomised Studies.

Fuertig R, Goettel M, Herich L, Hoefler J, Wiebe ST, Sharma V. Fuertig R, et al. CNS Drugs. 2023 Dec;37(12):1081-1097. doi: 10.1007/s40263-023-01041-4. Epub 2023 Nov 29. CNS Drugs. 2023. PMID: 38019355 Free PMC article. Clinical Trial.

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