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Structure-Permeability Relationship of Semipeptidic Macrocycles-Understanding and Optimizing Passive Permeability and Efflux Ratio.
Le Roux A, Blaise É, Boudreault PL, Comeau C, Doucet A, Giarrusso M, Collin MP, Neubauer T, Kölling F, Göller AH, Seep L, Tshitenge DT, Wittwer M, Kullmann M, Hillisch A, Mittendorf J, Marsault E. Le Roux A, et al. Among authors: boudreault pl. J Med Chem. 2020 Jul 9;63(13):6774-6783. doi: 10.1021/acs.jmedchem.0c00013. Epub 2020 May 26. J Med Chem. 2020. PMID: 32453569
Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids.
St-Georges C, Désilets A, Béliveau F, Ghinet M, Dion SP, Colombo É, Boudreault PL, Najmanovich RJ, Leduc R, Marsault É. St-Georges C, et al. Among authors: boudreault pl. Eur J Med Chem. 2017 Mar 31;129:110-123. doi: 10.1016/j.ejmech.2017.02.006. Epub 2017 Feb 11. Eur J Med Chem. 2017. PMID: 28219045
Discovery and Development of TMPRSS6 Inhibitors Modulating Hepcidin Levels in Human Hepatocytes.
Béliveau F, Tarkar A, Dion SP, Désilets A, Ghinet MG, Boudreault PL, St-Georges C, Marsault É, Paone D, Collins J, Macphee CH, Campobasso N, Groy A, Cottom J, Ouellette M, Pope AJ, Leduc R. Béliveau F, et al. Among authors: boudreault pl. Cell Chem Biol. 2019 Nov 21;26(11):1559-1572.e9. doi: 10.1016/j.chembiol.2019.09.004. Epub 2019 Sep 19. Cell Chem Biol. 2019. PMID: 31543462 Free article.
Modulation of the Passive Permeability of Semipeptidic Macrocycles: N- and C-Methylations Fine-Tune Conformation and Properties.
Comeau C, Ries B, Stadelmann T, Tremblay J, Poulet S, Fröhlich U, Côté J, Boudreault PL, Derbali RM, Sarret P, Grandbois M, Leclair G, Riniker S, Marsault É. Comeau C, et al. Among authors: boudreault pl. J Med Chem. 2021 May 13;64(9):5365-5383. doi: 10.1021/acs.jmedchem.0c02036. Epub 2021 Mar 22. J Med Chem. 2021. PMID: 33750117
Pharmacodynamic and pharmacokinetic profiles of a neurotensin receptor type 2 (NTS2) analgesic macrocyclic analog.
Chartier M, Desgagné M, Sousbie M, Rumsby C, Chevillard L, Théroux L, Haroune L, Côté J, Longpré JM, Boudreault PL, Marsault É, Sarret P. Chartier M, et al. Among authors: boudreault pl. Biomed Pharmacother. 2021 Sep;141:111861. doi: 10.1016/j.biopha.2021.111861. Epub 2021 Jul 3. Biomed Pharmacother. 2021. PMID: 34229249 Free article.
53 results