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An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria.
Lubkowicz D, Horvath NG, James MJ, Cantarella P, Renaud L, Bergeron CG, Shmueli RB, Anderson C, Gao JR, Kurtz CB, Perreault M, Charbonneau MR, Isabella VM, Hava DL. Lubkowicz D, et al. Among authors: gao jr. Mol Syst Biol. 2022 Mar;18(3):e10539. doi: 10.15252/msb.202110539. Mol Syst Biol. 2022. PMID: 35253995 Free PMC article.
Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice.
Kouno T, Zeng S, Wang Y, Duan Y, Lang S, Gao B, Hartmann P, Cabré N, Llorente C, Galbert C, Emond P, Sokol H, James M, Chao CC, Gao JR, Perreault M, Hava DL, Schnabl B. Kouno T, et al. Among authors: gao b, gao jr. Alcohol Clin Exp Res (Hoboken). 2023 May;47(5):856-867. doi: 10.1111/acer.15048. Epub 2023 Mar 19. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 36871955 Free PMC article.
Functional screening and rational design of compounds targeting GPR132 to treat diabetes.
Wang JL, Dou XD, Cheng J, Gao MX, Xu GF, Ding W, Ding JH, Li Y, Wang SH, Ji ZW, Zhao XY, Huo TY, Zhang CF, Liu YM, Sha XY, Gao JR, Zhang WH, Hao Y, Zhang C, Sun JP, Jiao N, Yu X. Wang JL, et al. Among authors: gao jr. Nat Metab. 2023 Oct;5(10):1726-1746. doi: 10.1038/s42255-023-00899-4. Epub 2023 Sep 28. Nat Metab. 2023. PMID: 37770763
132 results