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Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock.
Mandal P, Feng Y, Lyons JD, Berger SB, Otani S, DeLaney A, Tharp GK, Maner-Smith K, Burd EM, Schaeffer M, Hoffman S, Capriotti C, Roback L, Young CB, Liang Z, Ortlund EA, DiPaolo NC, Bosinger S, Bertin J, Gough PJ, Brodsky IE, Coopersmith CM, Shayakhmetov DM, Mocarski ES. Mandal P, et al. Immunity. 2018 Jul 17;49(1):42-55.e6. doi: 10.1016/j.immuni.2018.06.011. Immunity. 2018. PMID: 30021146 Free PMC article.
The Effect of Anticoagulants, Temperature, and Time on the Human Plasma Metabolome and Lipidome from Healthy Donors as Determined by Liquid Chromatography-Mass Spectrometry.
Khadka M, Todor A, Maner-Smith KM, Colucci JK, Tran V, Gaul DA, Anderson EJ, Natrajan MS, Rouphael N, Mulligan MJ, McDonald CE, Suthar M, Li S, Ortlund EA. Khadka M, et al. Biomolecules. 2019 May 23;9(5):200. doi: 10.3390/biom9050200. Biomolecules. 2019. PMID: 31126114 Free PMC article.
Alterations in the Human Plasma Lipidome in Response to Tularemia Vaccination.
Maner-Smith KM, Goll JB, Khadka M, Jensen TL, Colucci JK, Gelber CE, Albert CJ, Bosinger SE, Franke JD, Natrajan M, Rouphael N, Johnson RA, Sanz P, Anderson EJ, Hoft DF, Mulligan MJ, Ford DA, Ortlund EA. Maner-Smith KM, et al. Vaccines (Basel). 2020 Jul 24;8(3):414. doi: 10.3390/vaccines8030414. Vaccines (Basel). 2020. PMID: 32722213 Free PMC article.
TCA cycle remodeling drives proinflammatory signaling in humans with pulmonary tuberculosis.
Collins JM, Jones DP, Sharma A, Khadka M, Liu KH, Kempker RR, Prideaux B, Maner-Smith K, Tukvadze N, Shah NS, Brust JCM, Sékaly RP, Gandhi NR, Blumberg HM, Ortlund EA, Ziegler TR. Collins JM, et al. PLoS Pathog. 2021 Sep 24;17(9):e1009941. doi: 10.1371/journal.ppat.1009941. eCollection 2021 Sep. PLoS Pathog. 2021. PMID: 34559866 Free PMC article.
Microbial metabolite delta-valerobetaine is a diet-dependent obesogen.
Liu KH, Owens JA, Saeedi B, Cohen CE, Bellissimo MP, Naudin C, Darby T, Druzak S, Maner-Smith K, Orr M, Hu X, Fernandes J, Camacho MC, Hunter-Chang S, VanInsberghe D, Ma C, Ganesh T, Yeligar SM, Uppal K, Go YM, Alvarez JA, Vos MB, Ziegler TR, Woodworth MH, Kraft CS, Jones RM, Ortlund E, Neish AS, Jones DP. Liu KH, et al. Nat Metab. 2021 Dec;3(12):1694-1705. doi: 10.1038/s42255-021-00502-8. Epub 2021 Dec 20. Nat Metab. 2021. PMID: 34931082 Free PMC article.
APOE4 impairs myelination via cholesterol dysregulation in oligodendrocytes.
Blanchard JW, Akay LA, Davila-Velderrain J, von Maydell D, Mathys H, Davidson SM, Effenberger A, Chen CY, Maner-Smith K, Hajjar I, Ortlund EA, Bula M, Agbas E, Ng A, Jiang X, Kahn M, Blanco-Duque C, Lavoie N, Liu L, Reyes R, Lin YT, Ko T, R'Bibo L, Ralvenius WT, Bennett DA, Cam HP, Kellis M, Tsai LH. Blanchard JW, et al. Nature. 2022 Nov;611(7937):769-779. doi: 10.1038/s41586-022-05439-w. Epub 2022 Nov 16. Nature. 2022. PMID: 36385529 Free PMC article.
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