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The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase.
Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2020 Oct 28:2020.05.11.089375. doi: 10.1101/2020.05.11.089375. bioRxiv. 2020. Update in: J Virol. 2021 Jan 13;95(3):e01969-20. doi: 10.1128/JVI.01969-20 PMID: 32511412 Free PMC article. Updated. Preprint.
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Galasiti Kankanamalage AC, Kim Y, Damalanka VC, Rathnayake AD, Fehr AR, Mehzabeen N, Battaile KP, Lovell S, Lushington GH, Perlman S, Chang KO, Groutas WC. Galasiti Kankanamalage AC, et al. Among authors: fehr ar. Eur J Med Chem. 2018 Apr 25;150:334-346. doi: 10.1016/j.ejmech.2018.03.004. Epub 2018 Mar 6. Eur J Med Chem. 2018. PMID: 29544147 Free PMC article.
Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity.
Heer CD, Sanderson DJ, Voth LS, Alhammad YMO, Schmidt MS, Trammell SAJ, Perlman S, Cohen MS, Fehr AR, Brenner C. Heer CD, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2020 Oct 6:2020.04.17.047480. doi: 10.1101/2020.04.17.047480. bioRxiv. 2020. Update in: J Biol Chem. 2020 Dec 25;295(52):17986-17996. doi: 10.1074/jbc.RA120.015138 PMID: 32511303 Free PMC article. Updated. Preprint.
The SARS-CoV-2 Conserved Macrodomain Is a Mono-ADP-Ribosylhydrolase.
Alhammad YMO, Kashipathy MM, Roy A, Gagné JP, McDonald P, Gao P, Nonfoux L, Battaile KP, Johnson DK, Holmstrom ED, Poirier GG, Lovell S, Fehr AR. Alhammad YMO, et al. Among authors: fehr ar. J Virol. 2021 Jan 13;95(3):e01969-20. doi: 10.1128/JVI.01969-20. Print 2021 Jan 13. J Virol. 2021. PMID: 33158944 Free PMC article.
An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication.
Voth LS, O'Connor JJ, Kerr CM, Doerger E, Schwarting N, Sperstad P, Johnson DK, Fehr AR. Voth LS, et al. Among authors: fehr ar. bioRxiv [Preprint]. 2021 Mar 31:2021.03.30.437796. doi: 10.1101/2021.03.30.437796. bioRxiv. 2021. Update in: J Virol. 2021 Jul 12;95(15):e0076621. doi: 10.1128/JVI.00766-21 PMID: 33821264 Free PMC article. Updated. Preprint.
ADP-ribosyltransferases, an update on function and nomenclature.
Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, Filippov DV, Gagné JP, Grimaldi G, Guettler S, Hoch NC, Hottiger MO, Korn P, Kraus WL, Ladurner A, Lehtiö L, Leung AKL, Lord CJ, Mangerich A, Matic I, Matthews J, Moldovan GL, Moss J, Natoli G, Nielsen ML, Niepel M, Nolte F, Pascal J, Paschal BM, Pawłowski K, Poirier GG, Smith S, Timinszky G, Wang ZQ, Yélamos J, Yu X, Zaja R, Ziegler M. Lüscher B, et al. Among authors: fehr ar. FEBS J. 2022 Dec;289(23):7399-7410. doi: 10.1111/febs.16142. Epub 2021 Sep 13. FEBS J. 2022. PMID: 34323016 Free PMC article.
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain.
Dasovich M, Zhuo J, Goodman JA, Thomas A, McPherson RL, Jayabalan AK, Busa VF, Cheng SJ, Murphy BA, Redinger KR, Alhammad YMO, Fehr AR, Tsukamoto T, Slusher BS, Bosch J, Wei H, Leung AKL. Dasovich M, et al. Among authors: fehr ar. ACS Chem Biol. 2022 Jan 21;17(1):17-23. doi: 10.1021/acschembio.1c00721. Epub 2021 Dec 14. ACS Chem Biol. 2022. PMID: 34904435
62 results