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Repurposing erectile dysfunction drugs tadalafil and vardenafil to increase bone mass.
Kim SM, Taneja C, Perez-Pena H, Ryu V, Gumerova A, Li W, Ahmad N, Zhu LL, Liu P, Mathew M, Korkmaz F, Gera S, Sant D, Hadelia E, Ievleva K, Kuo TC, Miyashita H, Liu L, Tourkova I, Stanley S, Lizneva D, Iqbal J, Sun L, Tamler R, Blair HC, New MI, Haider S, Yuen T, Zaidi M. Kim SM, et al. Among authors: tourkova i. Proc Natl Acad Sci U S A. 2020 Jun 23;117(25):14386-14394. doi: 10.1073/pnas.2000950117. Epub 2020 Jun 8. Proc Natl Acad Sci U S A. 2020. PMID: 32513693 Free PMC article.
ACTH protects against glucocorticoid-induced osteonecrosis of bone.
Zaidi M, Sun L, Robinson LJ, Tourkova IL, Liu L, Wang Y, Zhu LL, Liu X, Li J, Peng Y, Yang G, Shi X, Levine A, Iqbal J, Yaroslavskiy BB, Isales C, Blair HC. Zaidi M, et al. Proc Natl Acad Sci U S A. 2010 May 11;107(19):8782-7. doi: 10.1073/pnas.0912176107. Epub 2010 Apr 26. Proc Natl Acad Sci U S A. 2010. PMID: 20421485 Free PMC article.
Blocking FSH action attenuates osteoclastogenesis.
Zhu LL, Tourkova I, Yuen T, Robinson LJ, Bian Z, Zaidi M, Blair HC. Zhu LL, et al. Among authors: tourkova i. Biochem Biophys Res Commun. 2012 May 25;422(1):54-8. doi: 10.1016/j.bbrc.2012.04.104. Epub 2012 Apr 27. Biochem Biophys Res Commun. 2012. PMID: 22561017 Free PMC article.
Blocking antibody to the β-subunit of FSH prevents bone loss by inhibiting bone resorption and stimulating bone synthesis.
Zhu LL, Blair H, Cao J, Yuen T, Latif R, Guo L, Tourkova IL, Li J, Davies TF, Sun L, Bian Z, Rosen C, Zallone A, New MI, Zaidi M. Zhu LL, et al. Among authors: tourkova il. Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14574-9. doi: 10.1073/pnas.1212806109. Epub 2012 Aug 20. Proc Natl Acad Sci U S A. 2012. PMID: 22908268 Free PMC article.
61 results