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New dual 5-HT1A and 5-HT7 receptor ligands derived from SYA16263.
Ofori E, Onyameh EK, Gonela UM, Voshavar C, Bricker B, Swanson TL, Eshleman AJ, Schmachtenberg JL, Bloom SH, Janowsky AJ, Ablordeppey SY. Ofori E, et al. Among authors: bloom sh. Eur J Med Chem. 2021 Mar 15;214:113243. doi: 10.1016/j.ejmech.2021.113243. Epub 2021 Feb 3. Eur J Med Chem. 2021. PMID: 33582388 Free PMC article.
Development of a Translational Model to Assess the Impact of Opioid Overdose and Naloxone Dosing on Respiratory Depression and Cardiac Arrest.
Mann J, Samieegohar M, Chaturbedi A, Zirkle J, Han X, Ahmadi SF, Eshleman A, Janowsky A, Wolfrum K, Swanson T, Bloom S, Dahan A, Olofsen E, Florian J, Strauss DG, Li Z. Mann J, et al. Clin Pharmacol Ther. 2022 Nov;112(5):1020-1032. doi: 10.1002/cpt.2696. Epub 2022 Jul 22. Clin Pharmacol Ther. 2022. PMID: 35766413
A highly D3R-selective and efficacious partial agonist (S)-ABS01-113 compared to its D3R-selective antagonist enantiomer (R)-ABS01-113 as potential treatments for opioid use disorder.
Galaj E, Bi GH, Klein B, Hempel B, Shaik AB, Gogarnoiu ES, Friedman J, Lam J, Rais R, Reed JF, Bloom SH, Swanson TL, Schmachtenberg JL, Eshleman AJ, Janowsky A, Xi ZX, Newman AH. Galaj E, et al. Among authors: bloom sh. Neuropsychopharmacology. 2022 Dec;47(13):2309-2318. doi: 10.1038/s41386-022-01379-1. Epub 2022 Jul 25. Neuropsychopharmacology. 2022. PMID: 35879349 Free PMC article.
Enantiomeric Separation, Absolute Configuration by X-ray Crystallographic Analysis, and Functional Evaluation of Enantiomers of the Dual Ligand, SYA0340 at 5-HT1A and 5-HT7A Receptors.
Bricker BA, Voshavar C, Onyameh EK, Gonela UM, Lin X, Swanson TL, Kozell LB, Schmachtenberg JL, Bloom SH, Janowsky AJ, Ablordeppey SY. Bricker BA, et al. Among authors: bloom sh. ACS Omega. 2023 Jun 7;8(24):21736-21744. doi: 10.1021/acsomega.3c01283. eCollection 2023 Jun 20. ACS Omega. 2023. PMID: 37360419 Free PMC article.
Astrocyte Dysfunction Induced by Alcohol in Females but Not Males.
Wilhelm CJ, Hashimoto JG, Roberts ML, Bloom SH, Andrew MR, Wiren KM. Wilhelm CJ, et al. Among authors: bloom sh. Brain Pathol. 2016 Jul;26(4):433-51. doi: 10.1111/bpa.12276. Epub 2015 Jul 14. Brain Pathol. 2016. PMID: 26088166 Free PMC article.
20 results