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A potent human monoclonal antibody with pan-neutralizing activities directly dislocates S trimer of SARS-CoV-2 through binding both up and down forms of RBD.
Wang X, Hu A, Chen X, Zhang Y, Yu F, Yue S, Li A, Zhang J, Pan Z, Yang Y, Lin Y, Gao L, Zhou J, Zhao J, Li F, Shi Y, Huang F, Yang X, Peng Y, Tu L, Zhang H, Zheng H, He J, Zhang H, Xu L, Huang Q, Zhu Y, Deng K, Ye L. Wang X, et al. Among authors: yang x, yang y. Signal Transduct Target Ther. 2022 Apr 5;7(1):114. doi: 10.1038/s41392-022-00954-8. Signal Transduct Target Ther. 2022. PMID: 35383141 Free PMC article.
Disease severity dictates SARS-CoV-2-specific neutralizing antibody responses in COVID-19.
Chen X, Pan Z, Yue S, Yu F, Zhang J, Yang Y, Li R, Liu B, Yang X, Gao L, Li Z, Lin Y, Huang Q, Xu L, Tang J, Hu L, Zhao J, Liu P, Zhang G, Chen Y, Deng K, Ye L. Chen X, et al. Among authors: yang x, yang y. Signal Transduct Target Ther. 2020 Sep 2;5(1):180. doi: 10.1038/s41392-020-00301-9. Signal Transduct Target Ther. 2020. PMID: 32879307 Free PMC article.
The adenosine analog prodrug ATV006 is orally bioavailable and has preclinical efficacy against parental SARS-CoV-2 and variants.
Cao L, Li Y, Yang S, Li G, Zhou Q, Sun J, Xu T, Yang Y, Liao R, Shi Y, Yang Y, Zhu T, Huang S, Ji Y, Cong F, Luo Y, Zhu Y, Luan H, Zhang H, Chen J, Liu X, Luo R, Liu L, Wang P, Yu Y, Xing F, Ke B, Zheng H, Deng X, Zhang W, Lin C, Shi M, Li CM, Zhang Y, Zhang L, Dai J, Lu H, Zhao J, Zhang X, Guo D. Cao L, et al. Among authors: yang s, yang y. Sci Transl Med. 2022 Sep 7;14(661):eabm7621. doi: 10.1126/scitranslmed.abm7621. Epub 2022 Sep 7. Sci Transl Med. 2022. PMID: 35579533 Free PMC article.
Advances in mRNA and other vaccines against MERS-CoV.
Tai W, Zhang X, Yang Y, Zhu J, Du L. Tai W, et al. Among authors: yang y. Transl Res. 2022 Apr;242:20-37. doi: 10.1016/j.trsl.2021.11.007. Epub 2021 Nov 19. Transl Res. 2022. PMID: 34801748 Free PMC article. Review.
Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptor.
Chen X, Li R, Pan Z, Qian C, Yang Y, You R, Zhao J, Liu P, Gao L, Li Z, Huang Q, Xu L, Tang J, Tian Q, Yao W, Hu L, Yan X, Zhou X, Wu Y, Deng K, Zhang Z, Qian Z, Chen Y, Ye L. Chen X, et al. Among authors: yang y. Cell Mol Immunol. 2020 Jun;17(6):647-649. doi: 10.1038/s41423-020-0426-7. Epub 2020 Apr 20. Cell Mol Immunol. 2020. PMID: 32313207 Free PMC article. No abstract available.
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