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Engineering the Human Fc Region Enables Direct Cell Killing by Cancer Glycan-Targeting Antibodies without the Need for Immune Effector Cells or Complement.
Vankemmelbeke M, McIntosh RS, Chua JX, Kirk T, Daniels I, Patsalidou M, Moss R, Parsons T, Scott D, Harris G, Ramage JM, Spendlove I, Durrant LG. Vankemmelbeke M, et al. Among authors: parsons t. Cancer Res. 2020 Aug 15;80(16):3399-3412. doi: 10.1158/0008-5472.CAN-19-3599. Epub 2020 Jun 12. Cancer Res. 2020. PMID: 32532823 Free PMC article.
Glycan-Based Near-infrared Fluorescent (NIRF) Imaging of Gastrointestinal Tumors: a Preclinical Proof-of-Concept In Vivo Study.
Houvast RD, Baart VM, Bhairosingh SS, Cordfunke RA, Chua JX, Vankemmelbeke M, Parsons T, Kuppen PJK, Durrant LG, Vahrmeijer AL, Sier CFM. Houvast RD, et al. Among authors: parsons t. Mol Imaging Biol. 2020 Dec;22(6):1511-1522. doi: 10.1007/s11307-020-01522-8. Epub 2020 Aug 11. Mol Imaging Biol. 2020. PMID: 32780212 Free PMC article.
SC134-TCB Targeting Fucosyl-GM1, a T Cell-Engaging Antibody with Potent Antitumor Activity in Preclinical Small Cell Lung Cancer Models.
Dave F, Vaghela P, Heath B, Dunster Z, Dubinina E, Thakker D, Mann K, Chadwick J, Cane G, Kaira BG, Mohammed OJ, Choudhury R, Paston S, Parsons T, Vankemmelbeke M, Durrant L. Dave F, et al. Among authors: parsons t. Mol Cancer Ther. 2024 Nov 4;23(11):1626-1638. doi: 10.1158/1535-7163.MCT-24-0187. Mol Cancer Ther. 2024. PMID: 39186309 Free PMC article.
660 results