García-Mera X - Search Results

1

X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A_2A Adenosine Receptor Antagonists.

Jespers W, Verdon G, Azuaje J, Majellaro M, Keränen H, García-Mera X, Congreve M, Deflorian F, de Graaf C, Zhukov A, Doré AS, Mason JS, Åqvist J, Cooke RM, Sotelo E, Gutiérrez-de-Terán H. Jespers W, et al. Angew Chem Int Ed Engl. 2020 Sep 14;59(38):16536-16543. doi: 10.1002/anie.202003788. Epub 2020 Jul 22. Angew Chem Int Ed Engl. 2020. PMID: 32542862 Free PMC article.

2

1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.

Fernández F, Caamaño O, Isabel Nieto M, López C, García-Mera X, Stefanachi A, Nicolotti O, Isabel Loza M, Brea J, Esteve C, Segarra V, Vidal B, Carotti A. Fernández F, et al. Bioorg Med Chem. 2009 May 15;17(10):3618-29. doi: 10.1016/j.bmc.2009.03.062. Epub 2009 Apr 5. Bioorg Med Chem. 2009. PMID: 19398343

3

Divergent solution-phase synthesis of diarylpyrimidine libraries as selective A3 adenosine receptor antagonists.

Yaziji V, Coelho A, El Maatougui A, Brea J, Loza MI, Garcia-Mera X, Sotelo E. Yaziji V, et al. J Comb Chem. 2009 Jul-Aug;11(4):519-22. doi: 10.1021/cc900044k. J Comb Chem. 2009. PMID: 19472983

4

Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.

Balo MC, Brea J, Caamaño O, Fernández F, García-Mera X, López C, Loza MI, Nieto MI, Rodríguez-Borges JE. Balo MC, et al. Bioorg Med Chem. 2009 Sep 15;17(18):6755-60. doi: 10.1016/j.bmc.2009.07.034. Epub 2009 Jul 23. Bioorg Med Chem. 2009. PMID: 19682912

5

Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.

Yaziji V, Rodríguez D, Gutiérrez-de-Terán H, Coelho A, Caamaño O, García-Mera X, Brea J, Loza MI, Cadavid MI, Sotelo E. Yaziji V, et al. J Med Chem. 2011 Jan 27;54(2):457-71. doi: 10.1021/jm100843z. Epub 2010 Dec 27. J Med Chem. 2011. PMID: 21186795

6

Selective and potent adenosine A3 receptor antagonists by methoxyaryl substitution on the N-(2,6-diarylpyrimidin-4-yl)acetamide scaffold.

Yaziji V, Rodríguez D, Coelho A, García-Mera X, El Maatougui A, Brea J, Loza MI, Cadavid MI, Gutiérrez-de-Terán H, Sotelo E. Yaziji V, et al. Eur J Med Chem. 2013 Jan;59:235-42. doi: 10.1016/j.ejmech.2012.11.010. Epub 2012 Nov 24. Eur J Med Chem. 2013. PMID: 23231967

7

Ugi-based approaches to quinoxaline libraries.

Azuaje J, El Maatougui A, García-Mera X, Sotelo E. Azuaje J, et al. ACS Comb Sci. 2014 Aug 11;16(8):403-11. doi: 10.1021/co500036n. Epub 2014 May 14. ACS Comb Sci. 2014. PMID: 24800648

8

Discovery of 3,4-Dihydropyrimidin-2(1H)-ones As a Novel Class of Potent and Selective A2B Adenosine Receptor Antagonists.

Crespo A, El Maatougui A, Biagini P, Azuaje J, Coelho A, Brea J, Loza MI, Cadavid MI, García-Mera X, Gutiérrez-de-Terán H, Sotelo E. Crespo A, et al. ACS Med Chem Lett. 2013 Oct 3;4(11):1031-6. doi: 10.1021/ml400185v. eCollection 2013 Nov 14. ACS Med Chem Lett. 2013. PMID: 24900602 Free PMC article.

9

Structure-based design of new KSP-Eg5 inhibitors assisted by a targeted multicomponent reaction.

Carbajales C, Prado MÁ, Gutiérrez-de-Terán H, Cores A, Azuaje J, Novio S, Nuñez MJ, Fernández-García B, Sotelo E, García-Mera X, Sánchez-Lazo P, Freire-Garabal M, Coelho A. Carbajales C, et al. Chembiochem. 2014 Jul 7;15(10):1471-80. doi: 10.1002/cbic.201402089. Epub 2014 Jun 18. Chembiochem. 2014. PMID: 24943831

10

Discovery of Potent and Highly Selective A2B Adenosine Receptor Antagonist Chemotypes.

El Maatougui A, Azuaje J, González-Gómez M, Miguez G, Crespo A, Carbajales C, Escalante L, García-Mera X, Gutiérrez-de-Terán H, Sotelo E. El Maatougui A, et al. J Med Chem. 2016 Mar 10;59(5):1967-83. doi: 10.1021/acs.jmedchem.5b01586. Epub 2016 Feb 9. J Med Chem. 2016. PMID: 26824742

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