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Diethyldithiocarbamate encapsulation reduces toxicity and promotes leishmanicidal effect through apoptosis-like mechanism in promastigote and ROS production by macrophage.
Assolini JP, Tomiotto-Pellissier F, da Silva Bortoleti BT, Gonçalves MD, Sahd CS, Carloto ACM, Feuser PE, Cordeiro AP, Borghi SM, Verri WA Jr, Sayer C, Hermes de Araújo PH, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Assolini JP, et al. Among authors: sahd cs. J Drug Target. 2020 Dec;28(10):1110-1123. doi: 10.1080/1061186X.2020.1783669. Epub 2020 Jun 30. J Drug Target. 2020. PMID: 32546016
4-nitrochalcone exerts leishmanicidal effect on L. amazonensis promastigotes and intracellular amastigotes, and the 4-nitrochalcone encapsulation in beeswax copaiba oil nanoparticles reduces macrophages cytotoxicity.
Assolini JP, da Silva TP, da Silva Bortoleti BT, Gonçalves MD, Tomiotto-Pellissier F, Sahd CS, Carloto ACM, Feuser PE, Cordeiro AP, Sayer C, Hermes de Araújo PH, Costa IN, Conchon-Costa I, Miranda-Sapla MM, Pavanelli WR. Assolini JP, et al. Among authors: sahd cs. Eur J Pharmacol. 2020 Oct 5;884:173392. doi: 10.1016/j.ejphar.2020.173392. Epub 2020 Jul 28. Eur J Pharmacol. 2020. PMID: 32735985 Free article.
Nanotechnology as a potential therapeutic alternative for schistosomiasis.
Tomiotto-Pellissier F, Miranda-Sapla MM, Machado LF, Bortoleti BTDS, Sahd CS, Chagas AF, Assolini JP, Oliveira FJA, Pavanelli WR, Conchon-Costa I, Costa IN, Melanda FN. Tomiotto-Pellissier F, et al. Among authors: sahd cs. Acta Trop. 2017 Oct;174:64-71. doi: 10.1016/j.actatropica.2017.06.025. Epub 2017 Jun 29. Acta Trop. 2017. PMID: 28668252 Review.