Schiller H - Search Results

1

Ribociclib Drug-Drug Interactions: Clinical Evaluations and Physiologically-Based Pharmacokinetic Modeling to Guide Drug Labeling.

Samant TS, Huth F, Umehara K, Schiller H, Dhuria SV, Elmeliegy M, Miller M, Chakraborty A, Heimbach T, He H, Ji Y. Samant TS, et al. Among authors: schiller h. Clin Pharmacol Ther. 2020 Sep;108(3):575-585. doi: 10.1002/cpt.1950. Epub 2020 Jul 25. Clin Pharmacol Ther. 2020. PMID: 32557601 Clinical Trial.

2

Esterase phenotyping in human liver in vitro: specificity of carboxylesterase inhibitors.

Umehara K, Zollinger M, Kigondu E, Witschi M, Juif C, Huth F, Schiller H, Chibale K, Camenisch G. Umehara K, et al. Among authors: schiller h. Xenobiotica. 2016 Oct;46(10):862-7. doi: 10.3109/00498254.2015.1133867. Epub 2016 Feb 18. Xenobiotica. 2016. PMID: 26887925

3

Improvement of the chemical inhibition phenotyping assay by cross-reactivity correction.

Njuguna NM, Umehara KI, Huth F, Schiller H, Chibale K, Camenisch G. Njuguna NM, et al. Among authors: schiller h. Drug Metab Pers Ther. 2016 Dec 1;31(4):221-228. doi: 10.1515/dmpt-2016-0028. Drug Metab Pers Ther. 2016. PMID: 27718490

4

Assessment of the pulmonary CYP1A1 metabolism of mavoglurant (AFQ056) in rat.

Yilmaz Y, Umehara K, Williams G, Faller T, Schiller H, Walles M, Kraehenbuehl S, Camenisch G, Manevski N. Yilmaz Y, et al. Among authors: schiller h. Xenobiotica. 2018 Aug;48(8):793-803. doi: 10.1080/00498254.2017.1373311. Epub 2017 Sep 29. Xenobiotica. 2018. PMID: 28879796

5

Estimation of fractions metabolized by hepatic CYP enzymes using a concept of inter-system extrapolation factors (ISEFs) - a comparison with the chemical inhibition method.

Umehara KI, Huth F, Gu H, Schiller H, Heimbach T, He H. Umehara KI, et al. Among authors: schiller h. Drug Metab Pers Ther. 2017 Dec 20;32(4):191-200. doi: 10.1515/dmpt-2017-0024. Drug Metab Pers Ther. 2017. PMID: 29176011

6

Examining P-gp efflux kinetics guided by the BDDCS - Rational selection of in vitro assay designs and mathematical models.

Riede J, Umehara KI, Schweigler P, Huth F, Schiller H, Camenisch G, Poller B. Riede J, et al. Among authors: schiller h. Eur J Pharm Sci. 2019 Apr 30;132:132-141. doi: 10.1016/j.ejps.2019.03.005. Epub 2019 Mar 9. Eur J Pharm Sci. 2019. PMID: 30857914

7

Drug-drug interaction (DDI) assessments of ruxolitinib, a dual substrate of CYP3A4 and CYP2C9, using a verified physiologically based pharmacokinetic (PBPK) model to support regulatory submissions.

Umehara K, Huth F, Jin Y, Schiller H, Aslanis V, Heimbach T, He H. Umehara K, et al. Among authors: schiller h. Drug Metab Pers Ther. 2019 May 30;34(2):/j/dmdi.2019.34.issue-2/dmpt-2018-0042/dmpt-2018-0042.xml. doi: 10.1515/dmpt-2018-0042. Drug Metab Pers Ther. 2019. PMID: 31145690

8

Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes.

Poller B, Woessner R, Barve A, Tillmann HC, Vemula J, Nica A, Elbast W, Schiller H, End P, Camenisch G, Weiss M. Poller B, et al. Among authors: schiller h. Pulm Pharmacol Ther. 2019 Aug;57:101809. doi: 10.1016/j.pupt.2019.101809. Epub 2019 Jun 10. Pulm Pharmacol Ther. 2019. PMID: 31195091

9

An integrated assessment of the ADME properties of the CDK4/6 Inhibitor ribociclib utilizing preclinical in vitro, in vivo, and human ADME data.

James AD, Schiller H, Marvalin C, Jin Y, Borell H, Roffel AF, Glaenzel U, Ji Y, Camenisch G. James AD, et al. Among authors: schiller h. Pharmacol Res Perspect. 2020 Jun;8(3):e00599. doi: 10.1002/prp2.599. Pharmacol Res Perspect. 2020. PMID: 32524755 Free PMC article. Clinical Trial.

10

Novel Bruton's Tyrosine Kinase inhibitor remibrutinib: Drug-drug interaction potential as a victim of CYP3A4 inhibitors based on clinical data and PBPK modeling.

Huth F, Schiller H, Jin Y, Poller B, Schuhler C, Weis W, Woessner R, Drollmann A, End P. Huth F, et al. Among authors: schiller h. Clin Transl Sci. 2022 Jan;15(1):118-129. doi: 10.1111/cts.13126. Epub 2021 Aug 25. Clin Transl Sci. 2022. PMID: 34432364 Free PMC article.

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