Morris ER - Search Results

1

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis.

Morris ER, Caswell SJ, Kunzelmann S, Arnold LH, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Nat Commun. 2020 Jun 23;11(1):3165. doi: 10.1038/s41467-020-16983-2. Nat Commun. 2020. PMID: 32576829 Free PMC article.

2

The missing link: allostery and catalysis in the anti-viral protein SAMHD1.

Morris ER, Taylor IA. Morris ER, et al. Biochem Soc Trans. 2019 Aug 30;47(4):1013-1027. doi: 10.1042/BST20180348. Epub 2019 Jul 11. Biochem Soc Trans. 2019. PMID: 31296733 Free PMC article. Review.

3

Positive selection in dNTPase SAMHD1 throughout mammalian evolution.

Monit C, Morris ER, Ruis C, Szafran B, Thiltgen G, Tsai MC, Mitchison NA, Bishop KN, Stoye JP, Taylor IA, Fassati A, Goldstein RA. Monit C, et al. Among authors: morris er. Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18647-18654. doi: 10.1073/pnas.1908755116. Epub 2019 Aug 26. Proc Natl Acad Sci U S A. 2019. PMID: 31451672 Free PMC article.

4

Probing the Catalytic Mechanism and Inhibition of SAMHD1 Using the Differential Properties of R_p- and S_p-dNTPαS Diastereomers.

Morris ER, Kunzelmann S, Caswell SJ, Purkiss AG, Kelly G, Taylor IA. Morris ER, et al. Biochemistry. 2021 Jun 1;60(21):1682-1698. doi: 10.1021/acs.biochem.0c00944. Epub 2021 May 14. Biochemistry. 2021. PMID: 33988981 Free PMC article.

5

Attenuation of reverse transcriptase facilitates SAMHD1 restriction of HIV-1 in cycling cells.

Tsai MC, Caswell SJ, Morris ER, Mann MC, Pennell S, Kelly G, Groom HCT, Taylor IA, Bishop KN. Tsai MC, et al. Among authors: morris er. Retrovirology. 2023 May 1;20(1):5. doi: 10.1186/s12977-023-00620-z. Retrovirology. 2023. PMID: 37127613 Free PMC article.

6

Platform-directed allostery and quaternary structure dynamics of SAMHD1 catalysis.

Acton OJ, Sheppard D, Kunzelmann S, Caswell SJ, Nans A, Burgess AJO, Kelly G, Morris ER, Rosenthal PB, Taylor IA. Acton OJ, et al. Among authors: morris er. Nat Commun. 2024 May 6;15(1):3775. doi: 10.1038/s41467-024-48237-w. Nat Commun. 2024. PMID: 38710701 Free PMC article.

7

Structural basis for DNA 3'-end processing by human tyrosyl-DNA phosphodiesterase 1.

Flett FJ, Ruksenaite E, Armstrong LA, Bharati S, Carloni R, Morris ER, Mackay CL, Interthal H, Richardson JM. Flett FJ, et al. Among authors: morris er. Nat Commun. 2018 Jan 2;9(1):24. doi: 10.1038/s41467-017-02530-z. Nat Commun. 2018. PMID: 29295983 Free PMC article.

8

Structural basis of Mos1 transposase inhibition by the anti-retroviral drug Raltegravir.

Wolkowicz UM, Morris ER, Robson M, Trubitsyna M, Richardson JM. Wolkowicz UM, et al. Among authors: morris er. ACS Chem Biol. 2014 Mar 21;9(3):743-51. doi: 10.1021/cb400791u. Epub 2014 Jan 10. ACS Chem Biol. 2014. PMID: 24397848 Free PMC article.

9

A bend, flip and trap mechanism for transposon integration.

Morris ER, Grey H, McKenzie G, Jones AC, Richardson JM. Morris ER, et al. Elife. 2016 May 25;5:e15537. doi: 10.7554/eLife.15537. Elife. 2016. PMID: 27223327 Free PMC article.

10

Graphical Dirichlet Process for Clustering Non-Exchangeable Grouped Data.

Chakrabarti A, Ni Y, Morris ERA, Salinas ML, Chapkin RS, Mallick BK. Chakrabarti A, et al. Among authors: morris era. J Mach Learn Res. 2024;25:323. J Mach Learn Res. 2024. PMID: 39691937 Free PMC article.

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