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The CHK1 inhibitor MU380 significantly increases the sensitivity of human docetaxel-resistant prostate cancer cells to gemcitabine through the induction of mitotic catastrophe.
Drápela S, Khirsariya P, van Weerden WM, Fedr R, Suchánková T, Búzová D, Červený J, Hampl A, Puhr M, Watson WR, Culig Z, Krejčí L, Paruch K, Souček K. Drápela S, et al. Among authors: krejci l. Mol Oncol. 2020 Oct;14(10):2487-2503. doi: 10.1002/1878-0261.12756. Epub 2020 Jul 16. Mol Oncol. 2020. PMID: 32579780 Free PMC article.
Synthesis and Profiling of a Novel Potent Selective Inhibitor of CHK1 Kinase Possessing Unusual N-trifluoromethylpyrazole Pharmacophore Resistant to Metabolic N-dealkylation.
Samadder P, Suchánková T, Hylse O, Khirsariya P, Nikulenkov F, Drápela S, Straková N, Vaňhara P, Vašíčková K, Kolářová H, Binó L, Bittová M, Ovesná P, Kollár P, Fedr R, Ešner M, Jaroš J, Hampl A, Krejčí L, Paruch K, Souček K. Samadder P, et al. Among authors: krejci l. Mol Cancer Ther. 2017 Sep;16(9):1831-1842. doi: 10.1158/1535-7163.MCT-17-0018. Epub 2017 Jun 15. Mol Cancer Ther. 2017. PMID: 28619751
Discovery of new inhibitors of nuclease MRE11.
Nikulenkov F, Carbain B, Biswas R, Havel S, Prochazkova J, Sisakova A, Zacpalova M, Chavdarova M, Marini V, Vsiansky V, Weisova V, Slavikova K, Biradar D, Khirsariya P, Vitek M, Sedlak D, Bartunek P, Daniel L, Brezovsky J, Damborsky J, Paruch K, Krejci L. Nikulenkov F, et al. Among authors: krejci l. Eur J Med Chem. 2025 Jan 1;285:117226. doi: 10.1016/j.ejmech.2024.117226. Online ahead of print. Eur J Med Chem. 2025. PMID: 39793442
Cancer TARGETases: DSB repair as a pharmacological target.
Samadder P, Aithal R, Belan O, Krejci L. Samadder P, et al. Among authors: krejci l. Pharmacol Ther. 2016 May;161:111-131. doi: 10.1016/j.pharmthera.2016.02.007. Epub 2016 Feb 18. Pharmacol Ther. 2016. PMID: 26899499 Review.
RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.
Di Marco S, Hasanova Z, Kanagaraj R, Chappidi N, Altmannova V, Menon S, Sedlackova H, Langhoff J, Surendranath K, Hühn D, Bhowmick R, Marini V, Ferrari S, Hickson ID, Krejci L, Janscak P. Di Marco S, et al. Among authors: krejci l. Mol Cell. 2017 Jun 1;66(5):658-671.e8. doi: 10.1016/j.molcel.2017.05.006. Mol Cell. 2017. PMID: 28575661 Free article.
211 results