McKinnie SMK - Search Results

1

Moving Pieces in a Cellular Puzzle: A Cryptic Peptide from the Scorpion Toxin Ts14 Activates AKT and ERK Signaling and Decreases Cardiac Myocyte Contractility via Dephosphorylation of Phospholamban.

Goméz-Mendoza DP, Lemos RP, Jesus ICG, Gorshkov V, McKinnie SMK, Vederas JC, Kjeldsen F, Guatimosim S, Santos RA, Pimenta AMC, Verano-Braga T. Goméz-Mendoza DP, et al. Among authors: mckinnie smk. J Proteome Res. 2020 Aug 7;19(8):3467-3477. doi: 10.1021/acs.jproteome.0c00290. Epub 2020 Jul 9. J Proteome Res. 2020. PMID: 32597192

2

The synthesis of active and stable diaminopimelate analogues of the lantibiotic peptide lactocin S.

Ross AC, McKinnie SM, Vederas JC. Ross AC, et al. J Am Chem Soc. 2012 Feb 1;134(4):2008-11. doi: 10.1021/ja211088m. Epub 2012 Jan 24. J Am Chem Soc. 2012. PMID: 22280450

3

Tityus serrulatus scorpion venom as a potential drug source for Chagas' disease: Trypanocidal and immunomodulatory activity.

Pimentel PMO, de Assis DRR, Gualdrón-Lopez M, Barroso A, Brant F, Leite PG, de Lima Oliveira BC, Esper L, McKinnie SMK, Vederas JC, do Nascimento Cordeiro M, Dos Reis PVM, Teixeira MM, de Castro Pimenta AM, Borges MH, de Lima ME, Machado FS. Pimentel PMO, et al. Among authors: mckinnie smk. Clin Immunol. 2021 May;226:108713. doi: 10.1016/j.clim.2021.108713. Epub 2021 Mar 9. Clin Immunol. 2021. PMID: 33711450

4

Solid-supported synthesis and biological evaluation of the lantibiotic peptide bis(desmethyl) lacticin 3147 A2.

Pattabiraman VR, McKinnie SM, Vederas JC. Pattabiraman VR, et al. Angew Chem Int Ed Engl. 2008;47(49):9472-5. doi: 10.1002/anie.200802919. Angew Chem Int Ed Engl. 2008. PMID: 18937239 No abstract available.

5

Targeting the apelin pathway as a novel therapeutic approach for cardiovascular diseases.

Zhong JC, Zhang ZZ, Wang W, McKinnie SMK, Vederas JC, Oudit GY. Zhong JC, et al. Among authors: mckinnie smk. Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):1942-1950. doi: 10.1016/j.bbadis.2016.11.007. Epub 2016 Nov 4. Biochim Biophys Acta Mol Basis Dis. 2017. PMID: 27825851 Free article. Review.

6

The Metalloprotease Neprilysin Degrades and Inactivates Apelin Peptides.

McKinnie SM, Fischer C, Tran KM, Wang W, Mosquera F, Oudit GY, Vederas JC. McKinnie SM, et al. Chembiochem. 2016 Aug 17;17(16):1495-8. doi: 10.1002/cbic.201600244. Epub 2016 Jul 5. Chembiochem. 2016. PMID: 27377680

7

Loss of Apelin exacerbates myocardial infarction adverse remodeling and ischemia-reperfusion injury: therapeutic potential of synthetic Apelin analogues.

Wang W, McKinnie SM, Patel VB, Haddad G, Wang Z, Zhabyeyev P, Das SK, Basu R, McLean B, Kandalam V, Penninger JM, Kassiri Z, Vederas JC, Murray AG, Oudit GY. Wang W, et al. J Am Heart Assoc. 2013 Jul 1;2(4):e000249. doi: 10.1161/JAHA.113.000249. J Am Heart Assoc. 2013. PMID: 23817469 Free PMC article.

8

Synthetic Modification within the "RPRL" Region of Apelin Peptides: Impact on Cardiovascular Activity and Stability to Neprilysin and Plasma Degradation.

McKinnie SMK, Wang W, Fischer C, McDonald T, Kalin KR, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC. McKinnie SMK, et al. J Med Chem. 2017 Jul 27;60(14):6408-6427. doi: 10.1021/acs.jmedchem.7b00723. Epub 2017 Jul 7. J Med Chem. 2017. PMID: 28685579

9

Plasma kallikrein cleaves and inactivates apelin-17: Palmitoyl- and PEG-extended apelin-17 analogs as metabolically stable blood pressure-lowering agents.

Fischer C, Lamer T, Wang W, McKinnie SMK, Iturrioz X, Llorens-Cortes C, Oudit GY, Vederas JC. Fischer C, et al. Among authors: mckinnie smk. Eur J Med Chem. 2019 Mar 15;166:119-124. doi: 10.1016/j.ejmech.2019.01.040. Epub 2019 Jan 18. Eur J Med Chem. 2019. PMID: 30690406

10

Angiotensin-Converting Enzyme 2 Metabolizes and Partially Inactivates Pyr-Apelin-13 and Apelin-17: Physiological Effects in the Cardiovascular System.

Wang W, McKinnie SM, Farhan M, Paul M, McDonald T, McLean B, Llorens-Cortes C, Hazra S, Murray AG, Vederas JC, Oudit GY. Wang W, et al. Hypertension. 2016 Aug;68(2):365-77. doi: 10.1161/HYPERTENSIONAHA.115.06892. Epub 2016 May 23. Hypertension. 2016. PMID: 27217402

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