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The ER chaperone calnexin controls mitochondrial positioning and respiration.
Gutiérrez T, Qi H, Yap MC, Tahbaz N, Milburn LA, Lucchinetti E, Lou PH, Zaugg M, LaPointe PG, Mercier P, Overduin M, Bischof H, Burgstaller S, Malli R, Ballanyi K, Shuai J, Simmen T. Gutiérrez T, et al. Among authors: simmen t. Sci Signal. 2020 Jun 30;13(638):eaax6660. doi: 10.1126/scisignal.aax6660. Sci Signal. 2020. PMID: 32606038
The subcellular distribution of calnexin is mediated by PACS-2.
Myhill N, Lynes EM, Nanji JA, Blagoveshchenskaya AD, Fei H, Carmine Simmen K, Cooper TJ, Thomas G, Simmen T. Myhill N, et al. Among authors: simmen t. Mol Biol Cell. 2008 Jul;19(7):2777-88. doi: 10.1091/mbc.e07-10-0995. Epub 2008 Apr 16. Mol Biol Cell. 2008. PMID: 18417615 Free PMC article.
Increased ER-mitochondrial coupling promotes mitochondrial respiration and bioenergetics during early phases of ER stress.
Bravo R, Vicencio JM, Parra V, Troncoso R, Munoz JP, Bui M, Quiroga C, Rodriguez AE, Verdejo HE, Ferreira J, Iglewski M, Chiong M, Simmen T, Zorzano A, Hill JA, Rothermel BA, Szabadkai G, Lavandero S. Bravo R, et al. Among authors: simmen t. J Cell Sci. 2011 Jul 1;124(Pt 13):2143-52. doi: 10.1242/jcs.080762. Epub 2011 May 31. J Cell Sci. 2011. PMID: 21628424 Free PMC article.
TMX1 determines cancer cell metabolism as a thiol-based modulator of ER-mitochondria Ca2+ flux.
Raturi A, Gutiérrez T, Ortiz-Sandoval C, Ruangkittisakul A, Herrera-Cruz MS, Rockley JP, Gesson K, Ourdev D, Lou PH, Lucchinetti E, Tahbaz N, Zaugg M, Baksh S, Ballanyi K, Simmen T. Raturi A, et al. Among authors: simmen t. J Cell Biol. 2016 Aug 15;214(4):433-44. doi: 10.1083/jcb.201512077. Epub 2016 Aug 8. J Cell Biol. 2016. PMID: 27502484 Free PMC article.
Rab32 connects ER stress to mitochondrial defects in multiple sclerosis.
Haile Y, Deng X, Ortiz-Sandoval C, Tahbaz N, Janowicz A, Lu JQ, Kerr BJ, Gutowski NJ, Holley JE, Eggleton P, Giuliani F, Simmen T. Haile Y, et al. Among authors: simmen t. J Neuroinflammation. 2017 Jan 23;14(1):19. doi: 10.1186/s12974-016-0788-z. J Neuroinflammation. 2017. PMID: 28115010 Free PMC article.
72 results