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Page 1
Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse.
González-Granillo M, Helguero LA, Alves E, Archer A, Savva C, Pedrelli M, Ahmed O, Li X, Domingues MR, Parini P, Gustafsson JÅ, Korach-André M. González-Granillo M, et al. Among authors: pedrelli m. Biol Sex Differ. 2019 Feb 26;10(1):11. doi: 10.1186/s13293-019-0225-y. Biol Sex Differ. 2019. PMID: 30808418 Free PMC article.
Hepatocyte-specific loss of GPS2 in mice reduces non-alcoholic steatohepatitis via activation of PPARα.
Liang N, Damdimopoulos A, Goñi S, Huang Z, Vedin LL, Jakobsson T, Giudici M, Ahmed O, Pedrelli M, Barilla S, Alzaid F, Mendoza A, Schröder T, Kuiper R, Parini P, Hollenberg A, Lefebvre P, Francque S, Van Gaal L, Staels B, Venteclef N, Treuter E, Fan R. Liang N, et al. Among authors: pedrelli m. Nat Commun. 2019 Apr 11;10(1):1684. doi: 10.1038/s41467-019-09524-z. Nat Commun. 2019. PMID: 30975991 Free PMC article.
Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans.
Minniti ME, Pedrelli M, Vedin LL, Delbès AS, Denis RGP, Öörni K, Sala C, Pirazzini C, Thiagarajan D, Nurmi HJ, Grompe M, Mills K, Garagnani P, Ellis ECS, Strom SC, Luquet SH, Wilson EM, Bial J, Steffensen KR, Parini P. Minniti ME, et al. Among authors: pedrelli m. Hepatology. 2020 Aug;72(2):656-670. doi: 10.1002/hep.31052. Epub 2020 Mar 23. Hepatology. 2020. PMID: 31785104 Free PMC article.
Generation of new hepatocyte-like in vitro models better resembling human lipid metabolism.
Pramfalk C, Jakobsson T, Verzijl CRC, Minniti ME, Obensa C, Ripamonti F, Olin M, Pedrelli M, Eriksson M, Parini P. Pramfalk C, et al. Among authors: pedrelli m. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Jun;1865(6):158659. doi: 10.1016/j.bbalip.2020.158659. Epub 2020 Feb 11. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 32058035
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice.
Pramfalk C, Ahmed O, Pedrelli M, Minniti ME, Luquet S, Denis RG, Olin M, Härdfeldt J, Vedin LL, Steffensen KR, Rydén M, Hodson L, Eriksson M, Parini P. Pramfalk C, et al. Among authors: pedrelli m. J Intern Med. 2022 Aug;292(2):296-307. doi: 10.1111/joim.13450. Epub 2022 Jan 13. J Intern Med. 2022. PMID: 34982494 Free article.
Mice with humanized livers reveal the role of hepatocyte clocks in rhythmic behavior.
Delbès AS, Quiñones M, Gobet C, Castel J, Denis RGP, Berthelet J, Weger BD, Challet E, Charpagne A, Metairon S, Piccand J, Kraus M, Rohde BH, Bial J, Wilson EM, Vedin LL, Minniti ME, Pedrelli M, Parini P, Gachon F, Luquet S. Delbès AS, et al. Among authors: pedrelli m. Sci Adv. 2023 May 19;9(20):eadf2982. doi: 10.1126/sciadv.adf2982. Epub 2023 May 17. Sci Adv. 2023. PMID: 37196091 Free PMC article.
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