Que NLS - Search Results

1

Molecular Stressors Engender Protein Connectivity Dysfunction through Aberrant N-Glycosylation of a Chaperone.

Yan P, Patel HJ, Sharma S, Corben A, Wang T, Panchal P, Yang C, Sun W, Araujo TL, Rodina A, Joshi S, Robzyk K, Gandu S, White JR, de Stanchina E, Modi S, Janjigian YY, Hill EG, Liu B, Erdjument-Bromage H, Neubert TA, Que NLS, Li Z, Gewirth DT, Taldone T, Chiosis G. Yan P, et al. Among authors: que nls. Cell Rep. 2020 Jun 30;31(13):107840. doi: 10.1016/j.celrep.2020.107840. Cell Rep. 2020. PMID: 32610141 Free PMC article.

2

Structural and Functional Analysis of GRP94 in the Closed State Reveals an Essential Role for the Pre-N Domain and a Potential Client-Binding Site.

Huck JD, Que NL, Hong F, Li Z, Gewirth DT. Huck JD, et al. Cell Rep. 2017 Sep 19;20(12):2800-2809. doi: 10.1016/j.celrep.2017.08.079. Cell Rep. 2017. PMID: 28930677 Free PMC article.

3

Exploring the Functional Complementation between Grp94 and Hsp90.

Maharaj KA, Que NL, Hong F, Huck JD, Gill SK, Wu S, Li Z, Gewirth DT. Maharaj KA, et al. PLoS One. 2016 Nov 8;11(11):e0166271. doi: 10.1371/journal.pone.0166271. eCollection 2016. PLoS One. 2016. PMID: 27824935 Free PMC article.

4

Structures of Hsp90α and Hsp90β bound to a purine-scaffold inhibitor reveal an exploitable residue for drug selectivity.

Huck JD, Que NLS, Sharma S, Taldone T, Chiosis G, Gewirth DT. Huck JD, et al. Among authors: que nls. Proteins. 2019 Oct;87(10):869-877. doi: 10.1002/prot.25750. Epub 2019 Jun 12. Proteins. 2019. PMID: 31141217 Free PMC article.

5

NECA derivatives exploit the paralog-specific properties of the site 3 side pocket of Grp94, the endoplasmic reticulum Hsp90.

Huck JD, Que NLS, Immormino RM, Shrestha L, Taldone T, Chiosis G, Gewirth DT. Huck JD, et al. Among authors: que nls. J Biol Chem. 2019 Nov 1;294(44):16010-16019. doi: 10.1074/jbc.RA119.009960. Epub 2019 Sep 9. J Biol Chem. 2019. PMID: 31501246 Free PMC article.

6

Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.

Que NLS, Crowley VM, Duerfeldt AS, Zhao J, Kent CN, Blagg BSJ, Gewirth DT. Que NLS, et al. J Med Chem. 2018 Apr 12;61(7):2793-2805. doi: 10.1021/acs.jmedchem.7b01608. Epub 2018 Mar 20. J Med Chem. 2018. PMID: 29528635 Free PMC article.

7

A deacylase in Rhizobium leguminosarum membranes that cleaves the 3-O-linked beta-hydroxymyristoyl moiety of lipid A precursors.

Basu SS, White KA, Que NL, Raetz CR. Basu SS, et al. J Biol Chem. 1999 Apr 16;274(16):11150-8. doi: 10.1074/jbc.274.16.11150. J Biol Chem. 1999. PMID: 10196200 Free PMC article.

8

Accumulation of a lipid A precursor lacking the 4'-phosphate following inactivation of the Escherichia coli lpxK gene.

Garrett TA, Que NL, Raetz CR. Garrett TA, et al. J Biol Chem. 1998 May 15;273(20):12457-65. doi: 10.1074/jbc.273.20.12457. J Biol Chem. 1998. PMID: 9575203 Free article.

9

Purification and mass spectrometry of six lipid A species from the bacterial endosymbiont Rhizobium etli. Demonstration of a conserved distal unit and a variable proximal portion.

Que NL, Lin S, Cotter RJ, Raetz CR. Que NL, et al. J Biol Chem. 2000 Sep 8;275(36):28006-16. doi: 10.1074/jbc.M004008200. J Biol Chem. 2000. PMID: 10856303 Free PMC article.

10

Two-dimensional NMR spectroscopy and structures of six lipid A species from Rhizobium etli CE3. Detection of an acyloxyacyl residue in each component and origin of the aminogluconate moiety.

Que NL, Ribeiro AA, Raetz CR. Que NL, et al. J Biol Chem. 2000 Sep 8;275(36):28017-27. doi: 10.1074/jbc.M004009200. J Biol Chem. 2000. PMID: 10856304 Free PMC article.

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