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IL13RA2-integrated genetically engineered mouse model allows for CAR T cells targeting pediatric high-grade gliomas.
Seblani M, Zannikou M, Duffy J, Levine R, Thakur A, Puigdelloses-Vallcorba M, Horbinski C, Miska J, Hambardzumyan D, Becher O, Balyasnikova I. Seblani M, et al. Among authors: puigdelloses vallcorba m. Res Sq [Preprint]. 2024 Dec 11:rs.3.rs-5398280. doi: 10.21203/rs.3.rs-5398280/v1. Res Sq. 2024. PMID: 39711568 Free PMC article. Preprint.
Microglia and monocyte-derived macrophages drive progression of pediatric high-grade gliomas and are transcriptionally shaped by histone mutations.
Ross JL, Puigdelloses-Vallcorba M, Piñero G, Soni N, Thomason W, DeSisto J, Angione A, Tsankova NM, Castro MG, Schniederjan M, Wadhwani NR, Raju GP, Morgenstern P, Becher OJ, Green AL, Tsankov AM, Hambardzumyan D. Ross JL, et al. Among authors: puigdelloses vallcorba m. Immunity. 2024 Nov 12;57(11):2669-2687.e6. doi: 10.1016/j.immuni.2024.09.007. Epub 2024 Oct 11. Immunity. 2024. PMID: 39395421
Monocyte depletion enhances neutrophil influx and proneural to mesenchymal transition in glioblastoma.
Chen Z, Soni N, Pinero G, Giotti B, Eddins DJ, Lindblad KE, Ross JL, Puigdelloses Vallcorba M, Joshi T, Angione A, Thomason W, Keane A, Tsankova NM, Gutmann DH, Lira SA, Lujambio A, Ghosn EEB, Tsankov AM, Hambardzumyan D. Chen Z, et al. Among authors: puigdelloses vallcorba m. Nat Commun. 2023 Apr 3;14(1):1839. doi: 10.1038/s41467-023-37361-8. Nat Commun. 2023. PMID: 37012245 Free PMC article.
Genetic driver mutations introduced in identical cell-of-origin in murine glioblastoma reveal distinct immune landscapes but similar response to checkpoint blockade.
Chen Z, Herting CJ, Ross JL, Gabanic B, Puigdelloses Vallcorba M, Szulzewsky F, Wojciechowicz ML, Cimino PJ, Ezhilarasan R, Sulman EP, Ying M, Ma'ayan A, Read RD, Hambardzumyan D. Chen Z, et al. Among authors: puigdelloses vallcorba m. Glia. 2020 Oct;68(10):2148-2166. doi: 10.1002/glia.23883. Epub 2020 Jul 8. Glia. 2020. PMID: 32639068 Free PMC article.