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8-CPT-cAMP/all-trans retinoic acid targets t(11;17) acute promyelocytic leukemia through enhanced cell differentiation and PLZF/RARα degradation.
Jiao B, Ren ZH, Liu P, Chen LJ, Shi JY, Dong Y, Ablain J, Shi L, Gao L, Hu JP, Ren RB, de Thé H, Chen Z, Chen SJ. Jiao B, et al. Among authors: gao l. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3495-500. doi: 10.1073/pnas.1222863110. Epub 2013 Feb 4. Proc Natl Acad Sci U S A. 2013. PMID: 23382200 Free PMC article.
Bortezomib interferes with C-KIT processing and transforms the t(8;21)-generated fusion proteins into tumor-suppressing fragments in leukemia cells.
Fang HT, Zhang B, Pan XF, Gao L, Zhen T, Zhao HX, Ma L, Xie J, Liu Z, Yu XJ, Cheng X, Feng TT, Zhang FX, Yang Y, Hu ZG, Sheng GQ, Chen YL, Chen SJ, Chen Z, Zhou GB. Fang HT, et al. Among authors: gao l. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2521-6. doi: 10.1073/pnas.1121341109. Epub 2012 Jan 27. Proc Natl Acad Sci U S A. 2012. PMID: 22308476 Free PMC article.
Oridonin, a diterpenoid extracted from medicinal herbs, targets AML1-ETO fusion protein and shows potent antitumor activity with low adverse effects on t(8;21) leukemia in vitro and in vivo.
Zhou GB, Kang H, Wang L, Gao L, Liu P, Xie J, Zhang FX, Weng XQ, Shen ZX, Chen J, Gu LJ, Yan M, Zhang DE, Chen SJ, Wang ZY, Chen Z. Zhou GB, et al. Among authors: gao l. Blood. 2007 Apr 15;109(8):3441-50. doi: 10.1182/blood-2006-06-032250. Epub 2006 Dec 29. Blood. 2007. PMID: 17197433 Free PMC article.
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