Pratt WB - Search Results

1

Low-Dose Hsp90 Inhibitor Selectively Radiosensitizes HNSCC and Pancreatic Xenografts.

Mehta RK, Pal S, Kondapi K, Sitto M, Dewar C, Devasia T, Schipper MJ, Thomas DG, Basrur V, Pai MP, Morishima Y, Osawa Y, Pratt WB, Lawrence TS, Nyati MK. Mehta RK, et al. Among authors: pratt wb. Clin Cancer Res. 2020 Oct 1;26(19):5246-5257. doi: 10.1158/1078-0432.CCR-19-3102. Epub 2020 Jul 27. Clin Cancer Res. 2020. PMID: 32718999 Free PMC article.

2

The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts.

Pratt WB, Morishima Y, Osawa Y. Pratt WB, et al. J Biol Chem. 2008 Aug 22;283(34):22885-9. doi: 10.1074/jbc.R800023200. Epub 2008 May 30. J Biol Chem. 2008. PMID: 18515355 Free PMC article. Review. No abstract available.

3

Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination.

Peng HM, Morishima Y, Clapp KM, Lau M, Pratt WB, Osawa Y. Peng HM, et al. Among authors: pratt wb. Biochemistry. 2009 Sep 8;48(35):8483-90. doi: 10.1021/bi901058g. Biochemistry. 2009. PMID: 19642705 Free PMC article.

4

Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage.

Pratt WB, Morishima Y, Peng HM, Osawa Y. Pratt WB, et al. Exp Biol Med (Maywood). 2010 Mar;235(3):278-89. doi: 10.1258/ebm.2009.009250. Exp Biol Med (Maywood). 2010. PMID: 20404045 Free PMC article. Review.

5

Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination.

Peng HM, Morishima Y, Pratt WB, Osawa Y. Peng HM, et al. Among authors: pratt wb. J Biol Chem. 2012 Jan 6;287(2):1556-65. doi: 10.1074/jbc.M111.323295. Epub 2011 Nov 28. J Biol Chem. 2012. PMID: 22128174 Free PMC article.

6

Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization.

Ahsan A, Ray D, Ramanand SG, Hegde A, Whitehead C, Rehemtulla A, Morishima Y, Pratt WB, Osawa Y, Lawrence TS, Nyati MK. Ahsan A, et al. Among authors: pratt wb. J Biol Chem. 2013 Sep 13;288(37):26879-86. doi: 10.1074/jbc.M113.492280. Epub 2013 Jul 29. J Biol Chem. 2013. PMID: 23897823 Free PMC article.

7

Efficacy of an EGFR-specific peptide against EGFR-dependent cancer cell lines and tumor xenografts.

Ahsan A, Ramanand SG, Bergin IL, Zhao L, Whitehead CE, Rehemtulla A, Ray D, Pratt WB, Lawrence TS, Nyati MK. Ahsan A, et al. Among authors: pratt wb. Neoplasia. 2014 Feb;16(2):105-14. doi: 10.1593/neo.14182. Neoplasia. 2014. PMID: 24709418 Free PMC article.

8

A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases.

Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. Pratt WB, et al. Exp Biol Med (Maywood). 2014 Nov;239(11):1405-13. doi: 10.1177/1535370214539444. Epub 2014 Jul 2. Exp Biol Med (Maywood). 2014. PMID: 24990484 Free PMC article. Review.

9

Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases.

Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Pratt WB, et al. Annu Rev Pharmacol Toxicol. 2015;55:353-71. doi: 10.1146/annurev-pharmtox-010814-124332. Epub 2014 Sep 25. Annu Rev Pharmacol Toxicol. 2015. PMID: 25292434 Free PMC article. Review.

10

ATM is the primary kinase responsible for phosphorylation of Hsp90α after ionizing radiation.

Elaimy AL, Ahsan A, Marsh K, Pratt WB, Ray D, Lawrence TS, Nyati MK. Elaimy AL, et al. Among authors: pratt wb. Oncotarget. 2016 Dec 13;7(50):82450-82457. doi: 10.18632/oncotarget.12557. Oncotarget. 2016. PMID: 27738310 Free PMC article.

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