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SGLT2 Inhibition Mediates Protection from Diabetic Kidney Disease by Promoting Ketone Body-Induced mTORC1 Inhibition.
Tomita I, Kume S, Sugahara S, Osawa N, Yamahara K, Yasuda-Yamahara M, Takeda N, Chin-Kanasaki M, Kaneko T, Mayoux E, Mark M, Yanagita M, Ogita H, Araki SI, Maegawa H. Tomita I, et al. Among authors: mark m. Cell Metab. 2020 Sep 1;32(3):404-419.e6. doi: 10.1016/j.cmet.2020.06.020. Epub 2020 Jul 28. Cell Metab. 2020. PMID: 32726607 Free article.
Combination of the sodium-glucose cotransporter-2 inhibitor empagliflozin with orlistat or sibutramine further improves the body-weight reduction and glucose homeostasis of obese rats fed a cafeteria diet.
Vickers SP, Cheetham SC, Headland KR, Dickinson K, Grempler R, Mayoux E, Mark M, Klein T. Vickers SP, et al. Among authors: mark m. Diabetes Metab Syndr Obes. 2014 Jul 1;7:265-75. doi: 10.2147/DMSO.S58786. eCollection 2014. Diabetes Metab Syndr Obes. 2014. PMID: 25061325 Free PMC article.
SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans.
Chae H, Augustin R, Gatineau E, Mayoux E, Bensellam M, Antoine N, Khattab F, Lai BK, Brusa D, Stierstorfer B, Klein H, Singh B, Ruiz L, Pieper M, Mark M, Herrera PL, Gribble FM, Reimann F, Wojtusciszyn A, Broca C, Rita N, Piemonti L, Gilon P. Chae H, et al. Among authors: mark m. Mol Metab. 2020 Dec;42:101071. doi: 10.1016/j.molmet.2020.101071. Epub 2020 Sep 5. Mol Metab. 2020. PMID: 32896668 Free PMC article.
687 results