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Page 1
Inhalation: A means to explore and optimize nintedanib's pharmacokinetic/pharmacodynamic relationship.
Epstein-Shochet G, Pham S, Beck S, Naiel S, Mekhael O, Revill S, Hayat A, Vierhout M, Bardestein-Wald B, Shitrit D, Ask K, Montgomery AB, Kolb MR, Surber MW. Epstein-Shochet G, et al. Among authors: mekhael o. Pulm Pharmacol Ther. 2020 Aug;63:101933. doi: 10.1016/j.pupt.2020.101933. Epub 2020 Aug 1. Pulm Pharmacol Ther. 2020. PMID: 32750409 Free article.
FK506-Binding Protein 13 Expression Is Upregulated in Interstitial Lung Disease and Correlated with Clinical Severity. A Potentially Protective Role.
Tat V, Ayaub EA, Ayoub A, Vierhout M, Naiel S, Padwal MK, Abed S, Mekhael O, Tandon K, Revill SD, Yousof T, Bellaye PS, Kolb PS, Dvorkin-Gheva A, Naqvi A, Cutz JC, Hambly N, Kato J, Vaughan M, Moss J, Kolb MRJ, Ask K. Tat V, et al. Among authors: mekhael o. Am J Respir Cell Mol Biol. 2021 Feb;64(2):235-246. doi: 10.1165/rcmb.2020-0121OC. Am J Respir Cell Mol Biol. 2021. PMID: 33253593 Free PMC article.
Cell-specific drug targeting in the lung.
Abed S, Turner R, Serniuck N, Tat V, Naiel S, Hayat A, Mekhael O, Vierhout M, Ask K, Rullo AF. Abed S, et al. Among authors: mekhael o. Biochem Pharmacol. 2021 Aug;190:114577. doi: 10.1016/j.bcp.2021.114577. Epub 2021 Apr 19. Biochem Pharmacol. 2021. PMID: 33887259 Review.
Mouse Models of Lung Fibrosis.
Mekhael O, Naiel S, Vierhout M, Hayat AI, Revill SD, Abed S, Inman MD, Kolb MRJ, Ask K. Mekhael O, et al. Methods Mol Biol. 2021;2299:291-321. doi: 10.1007/978-1-0716-1382-5_21. Methods Mol Biol. 2021. PMID: 34028751
Increased Monocyte-Derived CD11b+ Macrophage Subpopulations Following Cigarette Smoke Exposure Are Associated With Impaired Bleomycin-Induced Tissue Remodelling.
Cass SP, Mekhael O, Thayaparan D, McGrath JJC, Revill SD, Fantauzzi MF, Wang P, Reihani A, Hayat AI, Stevenson CS, Dvorkin-Gheva A, Botelho FM, Stämpfli MR, Ask K. Cass SP, et al. Among authors: mekhael o. Front Immunol. 2021 Sep 16;12:740330. doi: 10.3389/fimmu.2021.740330. eCollection 2021. Front Immunol. 2021. PMID: 34603325 Free PMC article.
IL-6 mediates ER expansion during hyperpolarization of alternatively activated macrophages.
Ayaub EA, Tandon K, Padwal M, Imani J, Patel H, Dubey A, Mekhael O, Upagupta C, Ayoub A, Dvorkin-Gheva A, Murphy J, Kolb PS, Lhotak S, Dickhout JG, Austin RC, Kolb MRJ, Richards CD, Ask K. Ayaub EA, et al. Among authors: mekhael o. Immunol Cell Biol. 2019 Feb;97(2):203-217. doi: 10.1111/imcb.12212. Epub 2018 Nov 14. Immunol Cell Biol. 2019. PMID: 30298952 Free PMC article.
Myeloid-specific deletion of activating transcription factor 6 alpha increases CD11b+ macrophage subpopulations and aggravates lung fibrosis.
Mekhael O, Revill SD, Hayat AI, Cass SP, MacDonald K, Vierhout M, Ayoub A, Reihani A, Padwal M, Imani J, Ayaub E, Yousof T, Dvorkin-Gheva A, Rullo A, Hirota JA, Richards CD, Bridgewater D, Stämpfli MR, Hambly N, Naqvi A, Kolb MR, Ask K. Mekhael O, et al. Immunol Cell Biol. 2023 May;101(5):412-427. doi: 10.1111/imcb.12637. Epub 2023 Apr 4. Immunol Cell Biol. 2023. PMID: 36862017