Pang L - Search Results

1

Synthesis and structural insights into the binding mode of the albomycin δ1 core and its analogues in complex with their target aminoacyl-tRNA synthetase.

Gadakh B, Vondenhoff G, Pang L, Nautiyal M, De Graef S, Strelkov SV, Weeks SD, Van Aerschot A. Gadakh B, et al. Among authors: pang l. Bioorg Med Chem. 2020 Sep 1;28(17):115645. doi: 10.1016/j.bmc.2020.115645. Epub 2020 Jul 13. Bioorg Med Chem. 2020. PMID: 32773091

2

Family-wide analysis of aminoacyl-sulfamoyl-3-deazaadenosine analogues as inhibitors of aminoacyl-tRNA synthetases.

Zhang B, De Graef S, Nautiyal M, Pang L, Gadakh B, Froeyen M, Van Mellaert L, Strelkov SV, Weeks SD, Van Aerschot A. Zhang B, et al. Among authors: pang l. Eur J Med Chem. 2018 Mar 25;148:384-396. doi: 10.1016/j.ejmech.2018.02.013. Epub 2018 Feb 14. Eur J Med Chem. 2018. PMID: 29477072

3

Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases.

Nautiyal M, De Graef S, Pang L, Gadakh B, Strelkov SV, Weeks SD, Van Aerschot A. Nautiyal M, et al. Among authors: pang l. Eur J Med Chem. 2019 Jul 1;173:154-166. doi: 10.1016/j.ejmech.2019.04.003. Epub 2019 Apr 5. Eur J Med Chem. 2019. PMID: 30995568

4

Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily.

De Ruysscher D, Pang L, De Graef S, Nautiyal M, De Borggraeve WM, Rozenski J, Strelkov SV, Weeks SD, Van Aerschot A. De Ruysscher D, et al. Among authors: pang l. Eur J Med Chem. 2019 Jul 15;174:252-264. doi: 10.1016/j.ejmech.2019.04.045. Epub 2019 Apr 17. Eur J Med Chem. 2019. PMID: 31048140

5

Synthesis and Biological Evaluation of Lipophilic Nucleoside Analogues as Inhibitors of Aminoacyl-tRNA Synthetases.

Nautiyal M, Gadakh B, De Graef S, Pang L, Khan M, Xun Y, Rozenski J, Van Aerschot A. Nautiyal M, et al. Among authors: pang l. Antibiotics (Basel). 2019 Oct 9;8(4):180. doi: 10.3390/antibiotics8040180. Antibiotics (Basel). 2019. PMID: 31600972 Free PMC article.

6

Structural Insights into the Binding of Natural Pyrimidine-Based Inhibitors of Class II Aminoacyl-tRNA Synthetases.

Pang L, Nautiyal M, De Graef S, Gadakh B, Zorzini V, Economou A, Strelkov SV, Van Aerschot A, Weeks SD. Pang L, et al. ACS Chem Biol. 2020 Feb 21;15(2):407-415. doi: 10.1021/acschembio.9b00887. Epub 2020 Jan 8. ACS Chem Biol. 2020. PMID: 31869198

7

Phenyltriazole-functionalized sulfamate inhibitors targeting tyrosyl- or isoleucyl-tRNA synthetase.

De Ruysscher D, Pang L, Mattelaer CA, Nautiyal M, De Graef S, Rozenski J, Strelkov SV, Lescrinier E, Weeks SD, Van Aerschot A. De Ruysscher D, et al. Among authors: pang l. Bioorg Med Chem. 2020 Aug 1;28(15):115580. doi: 10.1016/j.bmc.2020.115580. Epub 2020 Jun 5. Bioorg Med Chem. 2020. PMID: 32631562

8

Synthesis and Biological Evaluation of 1,3-Dideazapurine-Like 7-Amino-5-Hydroxymethyl-Benzimidazole Ribonucleoside Analogues as Aminoacyl-tRNA Synthetase Inhibitors.

Zhang B, Pang L, Nautiyal M, De Graef S, Gadakh B, Lescrinier E, Rozenski J, Strelkov SV, Weeks SD, Van Aerschot A. Zhang B, et al. Among authors: pang l. Molecules. 2020 Oct 16;25(20):4751. doi: 10.3390/molecules25204751. Molecules. 2020. PMID: 33081246 Free PMC article.

9

Synthesis and structure-activity studies of novel anhydrohexitol-based Leucyl-tRNA synthetase inhibitors.

De Ruysscher D, Pang L, Lenders SMG, Cappoen D, Cos P, Rozenski J, Strelkov SV, Weeks SD, Van Aerschot A. De Ruysscher D, et al. Among authors: pang l. Eur J Med Chem. 2021 Feb 5;211:113021. doi: 10.1016/j.ejmech.2020.113021. Epub 2020 Nov 16. Eur J Med Chem. 2021. PMID: 33248851

10

Aminoacyl-tRNA Synthetases as Valuable Targets for Antimicrobial Drug Discovery.

Pang L, Weeks SD, Van Aerschot A. Pang L, et al. Int J Mol Sci. 2021 Feb 10;22(4):1750. doi: 10.3390/ijms22041750. Int J Mol Sci. 2021. PMID: 33578647 Free PMC article. Review.

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