Ojha A - Search Results

1

A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice.

Laczkó D, Hogan MJ, Toulmin SA, Hicks P, Lederer K, Gaudette BT, Castaño D, Amanat F, Muramatsu H, Oguin TH 3rd, Ojha A, Zhang L, Mu Z, Parks R, Manzoni TB, Roper B, Strohmeier S, Tombácz I, Arwood L, Nachbagauer R, Karikó K, Greenhouse J, Pessaint L, Porto M, Putman-Taylor T, Strasbaugh A, Campbell TA, Lin PJC, Tam YK, Sempowski GD, Farzan M, Choe H, Saunders KO, Haynes BF, Andersen H, Eisenlohr LC, Weissman D, Krammer F, Bates P, Allman D, Locci M, Pardi N. Laczkó D, et al. Among authors: ojha a. Immunity. 2020 Oct 13;53(4):724-732.e7. doi: 10.1016/j.immuni.2020.07.019. Epub 2020 Jul 30. Immunity. 2020. PMID: 32783919 Free PMC article.

2

The D614G mutation in the SARS-CoV-2 spike protein reduces S1 shedding and increases infectivity.

Zhang L, Jackson CB, Mou H, Ojha A, Rangarajan ES, Izard T, Farzan M, Choe H. Zhang L, et al. Among authors: ojha a. bioRxiv [Preprint]. 2020 Jun 12:2020.06.12.148726. doi: 10.1101/2020.06.12.148726. bioRxiv. 2020. Update in: Nat Commun. 2020 Nov 26;11(1):6013. doi: 10.1038/s41467-020-19808-4 PMID: 32587973 Free PMC article. Updated. Preprint.

3

Phosphatidylethanolamine and Phosphatidylserine Synergize To Enhance GAS6/AXL-Mediated Virus Infection and Efferocytosis.

Zhang L, Richard AS, Jackson CB, Ojha A, Choe H. Zhang L, et al. Among authors: ojha a. J Virol. 2020 Dec 22;95(2):e02079-20. doi: 10.1128/JVI.02079-20. Print 2020 Dec 22. J Virol. 2020. PMID: 33115868 Free PMC article.

4

An engineered receptor-binding domain improves the immunogenicity of multivalent SARS-CoV-2 vaccines.

Quinlan BD, He W, Mou H, Zhang L, Guo Y, Chang J, Peng S, Ojha A, Tavora R, Parcells MS, Luo G, Li W, Zhong G, Choe H, Farzan M. Quinlan BD, et al. Among authors: ojha a. bioRxiv [Preprint]. 2020 Nov 18:2020.11.18.388934. doi: 10.1101/2020.11.18.388934. bioRxiv. 2020. Update in: mBio. 2021 May 11;12(3):e00930-21. doi: 10.1128/mBio.00930-21 PMID: 33236008 Free PMC article. Updated. Preprint.

5

SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity.

Zhang L, Jackson CB, Mou H, Ojha A, Peng H, Quinlan BD, Rangarajan ES, Pan A, Vanderheiden A, Suthar MS, Li W, Izard T, Rader C, Farzan M, Choe H. Zhang L, et al. Among authors: ojha a. Nat Commun. 2020 Nov 26;11(1):6013. doi: 10.1038/s41467-020-19808-4. Nat Commun. 2020. PMID: 33243994 Free PMC article.

6

AAV vectors engineered to target insulin receptor greatly enhance intramuscular gene delivery.

Jackson CB, Richard AS, Ojha A, Conkright KA, Trimarchi JM, Bailey CC, Alpert MD, Kay MA, Farzan M, Choe H. Jackson CB, et al. Among authors: ojha a. Mol Ther Methods Clin Dev. 2020 Nov 17;19:496-506. doi: 10.1016/j.omtm.2020.11.004. eCollection 2020 Dec 11. Mol Ther Methods Clin Dev. 2020. PMID: 33313337 Free PMC article.

7

Hydroxychloroquine-mediated inhibition of SARS-CoV-2 entry is attenuated by TMPRSS2.

Ou T, Mou H, Zhang L, Ojha A, Choe H, Farzan M. Ou T, et al. Among authors: ojha a. PLoS Pathog. 2021 Jan 19;17(1):e1009212. doi: 10.1371/journal.ppat.1009212. eCollection 2021 Jan. PLoS Pathog. 2021. PMID: 33465165 Free PMC article.

8

An Engineered Receptor-Binding Domain Improves the Immunogenicity of Multivalent SARS-CoV-2 Vaccines.

Guo Y, He W, Mou H, Zhang L, Chang J, Peng S, Ojha A, Tavora R, Parcells MS, Luo G, Li W, Zhong G, Choe H, Farzan M, Quinlan BD. Guo Y, et al. Among authors: ojha a. mBio. 2021 May 11;12(3):e00930-21. doi: 10.1128/mBio.00930-21. mBio. 2021. PMID: 33975938 Free PMC article.

9

Cytoplasmic Tail Truncation Stabilizes S1-S2 Association and Enhances S Protein Incorporation into SARS-CoV-2 Pseudovirions.

Zhang L, Hom N, Ojha A, Lovendahl KN, Mou H, Lee KK, Choe H. Zhang L, et al. Among authors: ojha a. J Virol. 2023 Mar 30;97(3):e0165022. doi: 10.1128/jvi.01650-22. Epub 2023 Feb 15. J Virol. 2023. PMID: 36790205 Free PMC article.

10

Effect of mRNA-LNP components of two globally-marketed COVID-19 vaccines on efficacy and stability.

Zhang L, More KR, Ojha A, Jackson CB, Quinlan BD, Li H, He W, Farzan M, Pardi N, Choe H. Zhang L, et al. Among authors: ojha a. NPJ Vaccines. 2023 Oct 11;8(1):156. doi: 10.1038/s41541-023-00751-6. NPJ Vaccines. 2023. PMID: 37821446 Free PMC article.

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