Hau R - Search Results

1

Investigation of the Drug Resistance Mechanism of M2-S31N Channel Blockers through Biomolecular Simulations and Viral Passage Experiments.

Musharrafieh R, Lagarias P, Ma C, Hau R, Romano A, Lambrinidis G, Kolocouris A, Wang J. Musharrafieh R, et al. Among authors: hau r. ACS Pharmacol Transl Sci. 2020 Mar 31;3(4):666-675. doi: 10.1021/acsptsci.0c00018. eCollection 2020 Aug 14. ACS Pharmacol Transl Sci. 2020. PMID: 32832869 Free PMC article.

2

Discovery of dapivirine, a nonnucleoside HIV-1 reverse transcriptase inhibitor, as a broad-spectrum antiviral against both influenza A and B viruses.

Hu Y, Zhang J, Musharrafieh RG, Ma C, Hau R, Wang J. Hu Y, et al. Among authors: hau r. Antiviral Res. 2017 Sep;145:103-113. doi: 10.1016/j.antiviral.2017.07.016. Epub 2017 Aug 2. Antiviral Res. 2017. PMID: 28778830 Free PMC article.

3

Chemical Genomics Approach Leads to the Identification of Hesperadin, an Aurora B Kinase Inhibitor, as a Broad-Spectrum Influenza Antiviral.

Hu Y, Zhang J, Musharrafieh R, Hau R, Ma C, Wang J. Hu Y, et al. Among authors: hau r. Int J Mol Sci. 2017 Sep 8;18(9):1929. doi: 10.3390/ijms18091929. Int J Mol Sci. 2017. PMID: 28885544 Free PMC article.

4

In Vitro Pharmacokinetic Optimizations of AM2-S31N Channel Blockers Led to the Discovery of Slow-Binding Inhibitors with Potent Antiviral Activity against Drug-Resistant Influenza A Viruses.

Wang Y, Hu Y, Xu S, Zhang Y, Musharrafieh R, Hau RK, Ma C, Wang J. Wang Y, et al. Among authors: hau rk. J Med Chem. 2018 Feb 8;61(3):1074-1085. doi: 10.1021/acs.jmedchem.7b01536. Epub 2018 Jan 17. J Med Chem. 2018. PMID: 29341607 Free PMC article.

5

Structure-Property Relationship Studies of Influenza A Virus AM2-S31N Proton Channel Blockers.

Hu Y, Hau RK, Wang Y, Tuohy P, Zhang Y, Xu S, Ma C, Wang J. Hu Y, et al. ACS Med Chem Lett. 2018 Oct 3;9(11):1111-1116. doi: 10.1021/acsmedchemlett.8b00336. eCollection 2018 Nov 8. ACS Med Chem Lett. 2018. PMID: 30429954 Free PMC article.

6

Identification of NMS-873, an allosteric and specific p97 inhibitor, as a broad antiviral against both influenza A and B viruses.

Zhang J, Hu Y, Hau R, Musharrafieh R, Ma C, Zhou X, Chen Y, Wang J. Zhang J, et al. Among authors: hau r. Eur J Pharm Sci. 2019 May 15;133:86-94. doi: 10.1016/j.ejps.2019.03.020. Epub 2019 Mar 28. Eur J Pharm Sci. 2019. PMID: 30930289 Free PMC article.

7

PF-07321332 (Nirmatrelvir) does not interact with human ENT1 or ENT2: Implications for COVID-19 patients.

Hau RK, Wright SH, Cherrington NJ. Hau RK, et al. Clin Transl Sci. 2022 Jul;15(7):1599-1605. doi: 10.1111/cts.13292. Epub 2022 May 16. Clin Transl Sci. 2022. PMID: 35505633 Free PMC article.

8

Predicting Drug Interactions with Human Equilibrative Nucleoside Transporters 1 and 2 Using Functional Knockout Cell Lines and Bayesian Modeling.

Miller SR, Zhang X, Hau RK, Jilek JL, Jennings EQ, Galligan JJ, Foil DH, Zorn KM, Ekins S, Wright SH, Cherrington NJ. Miller SR, et al. Among authors: hau rk. Mol Pharmacol. 2021 Feb;99(2):147-162. doi: 10.1124/molpharm.120.000169. Epub 2020 Dec 1. Mol Pharmacol. 2021. PMID: 33262250 Free PMC article.

9

Transporter Inhibition Profile for the Antivirals Tilorone, Quinacrine and Pyronaridine.

Vignaux PA, Lane TR, Puhl AC, Hau RK, Wright SH, Cherrington NJ, Ekins S. Vignaux PA, et al. Among authors: hau rk. ACS Omega. 2023 Mar 24;8(13):12532-12537. doi: 10.1021/acsomega.3c00724. eCollection 2023 Apr 4. ACS Omega. 2023. PMID: 37033868 Free PMC article.

10

Addressing the Clinical Importance of Equilibrative Nucleoside Transporters in Drug Discovery and Development.

Hau RK, Wright SH, Cherrington NJ. Hau RK, et al. Clin Pharmacol Ther. 2023 Oct;114(4):780-794. doi: 10.1002/cpt.2984. Epub 2023 Jul 21. Clin Pharmacol Ther. 2023. PMID: 37404197 Free PMC article. Review.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

82 results

Search Page

Filters