Wang J - Search Results

1

Investigation of the Drug Resistance Mechanism of M2-S31N Channel Blockers through Biomolecular Simulations and Viral Passage Experiments.

Musharrafieh R, Lagarias P, Ma C, Hau R, Romano A, Lambrinidis G, Kolocouris A, Wang J. Musharrafieh R, et al. Among authors: wang j. ACS Pharmacol Transl Sci. 2020 Mar 31;3(4):666-675. doi: 10.1021/acsptsci.0c00018. eCollection 2020 Aug 14. ACS Pharmacol Transl Sci. 2020. PMID: 32832869 Free PMC article.

2

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus.

Wang J, Ma C, Balannik V, Pinto LH, Lamb RA, Degrado WF. Wang J, et al. ACS Med Chem Lett. 2011 Apr 14;2(4):307-312. doi: 10.1021/ml100297w. ACS Med Chem Lett. 2011. PMID: 21691418 Free PMC article.

3

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

Wang J, Ma C, Fiorin G, Carnevale V, Wang T, Hu F, Lamb RA, Pinto LH, Hong M, Klein ML, DeGrado WF. Wang J, et al. Among authors: wang t. J Am Chem Soc. 2011 Aug 17;133(32):12834-41. doi: 10.1021/ja204969m. Epub 2011 Jul 21. J Am Chem Soc. 2011. PMID: 21744829 Free PMC article.

4

Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel.

Wang J, Ma C, Wu Y, Lamb RA, Pinto LH, DeGrado WF. Wang J, et al. J Am Chem Soc. 2011 Sep 7;133(35):13844-7. doi: 10.1021/ja2050666. Epub 2011 Aug 12. J Am Chem Soc. 2011. PMID: 21819109 Free PMC article.

5

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus.

Wang J, Wu Y, Ma C, Fiorin G, Wang J, Pinto LH, Lamb RA, Klein ML, Degrado WF. Wang J, et al. Proc Natl Acad Sci U S A. 2013 Jan 22;110(4):1315-20. doi: 10.1073/pnas.1216526110. Epub 2013 Jan 9. Proc Natl Acad Sci U S A. 2013. PMID: 23302696 Free PMC article.

6

Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay.

Balgi AD, Wang J, Cheng DY, Ma C, Pfeifer TA, Shimizu Y, Anderson HJ, Pinto LH, Lamb RA, DeGrado WF, Roberge M. Balgi AD, et al. Among authors: wang j. PLoS One. 2013;8(2):e55271. doi: 10.1371/journal.pone.0055271. Epub 2013 Feb 1. PLoS One. 2013. PMID: 23383318 Free PMC article.

7

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus.

Wang J, Ma C, Wang J, Jo H, Canturk B, Fiorin G, Pinto LH, Lamb RA, Klein ML, DeGrado WF. Wang J, et al. J Med Chem. 2013 Apr 11;56(7):2804-12. doi: 10.1021/jm301538e. Epub 2013 Mar 27. J Med Chem. 2013. PMID: 23437766 Free PMC article.

8

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

Wu Y, Canturk B, Jo H, Ma C, Gianti E, Klein ML, Pinto LH, Lamb RA, Fiorin G, Wang J, DeGrado WF. Wu Y, et al. Among authors: wang j. J Am Chem Soc. 2014 Dec 31;136(52):17987-95. doi: 10.1021/ja508461m. Epub 2014 Dec 18. J Am Chem Soc. 2014. PMID: 25470189 Free PMC article.

9

Recent progress in designing inhibitors that target the drug-resistant M2 proton channels from the influenza A viruses.

Wang J, Li F, Ma C. Wang J, et al. Biopolymers. 2015 Jul;104(4):291-309. doi: 10.1002/bip.22623. Biopolymers. 2015. PMID: 25663018

10

Discovery of Highly Potent Inhibitors Targeting the Predominant Drug-Resistant S31N Mutant of the Influenza A Virus M2 Proton Channel.

Li F, Ma C, DeGrado WF, Wang J. Li F, et al. Among authors: wang j. J Med Chem. 2016 Feb 11;59(3):1207-16. doi: 10.1021/acs.jmedchem.5b01910. Epub 2016 Jan 29. J Med Chem. 2016. PMID: 26771709 Free PMC article.

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