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Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
Shen YA, Hong J, Asaka R, Asaka S, Hsu FC, Suryo Rahmanto Y, Jung JG, Chen YW, Yen TT, Tomaszewski A, Zhang C, Attarwala N, DeMarzo AM, Davidson B, Chuang CM, Chen X, Gaillard S, Le A, Shih IM, Wang TL. Shen YA, et al. Among authors: le a. Cancer Res. 2020 Oct 15;80(20):4514-4526. doi: 10.1158/0008-5472.CAN-19-3971. Epub 2020 Aug 28. Cancer Res. 2020. PMID: 32859605 Free PMC article.
Uncovering the Role of N-Acetyl-Aspartyl-Glutamate as a Glutamate Reservoir in Cancer.
Nguyen T, Kirsch BJ, Asaka R, Nabi K, Quinones A, Tan J, Antonio MJ, Camelo F, Li T, Nguyen S, Hoang G, Nguyen K, Udupa S, Sazeides C, Shen YA, Elgogary A, Reyes J, Zhao L, Kleensang A, Chaichana KL, Hartung T, Betenbaugh MJ, Marie SK, Jung JG, Wang TL, Gabrielson E, Le A. Nguyen T, et al. Among authors: le a. Cell Rep. 2019 Apr 9;27(2):491-501.e6. doi: 10.1016/j.celrep.2019.03.036. Cell Rep. 2019. PMID: 30970252 Free PMC article.
Upregulation of the Glutaminase II Pathway Contributes to Glutamate Production upon Glutaminase 1 Inhibition in Pancreatic Cancer.
Udupa S, Nguyen S, Hoang G, Nguyen T, Quinones A, Pham K, Asaka R, Nguyen K, Zhang C, Elgogary A, Jung JG, Xu Q, Fu J, Thomas AG, Tsukamoto T, Hanes J, Slusher BS, Cooper AJL, Le A. Udupa S, et al. Among authors: le a. Proteomics. 2019 Nov;19(21-22):e1800451. doi: 10.1002/pmic.201800451. Epub 2019 Aug 1. Proteomics. 2019. PMID: 31231915 Free PMC article.
Mitochondrial copper depletion suppresses triple-negative breast cancer in mice.
Cui L, Gouw AM, LaGory EL, Guo S, Attarwala N, Tang Y, Qi J, Chen YS, Gao Z, Casey KM, Bazhin AA, Chen M, Hu L, Xie J, Fang M, Zhang C, Zhu Q, Wang Z, Giaccia AJ, Gambhir SS, Zhu W, Felsher DW, Pegram MD, Goun EA, Le A, Rao J. Cui L, et al. Among authors: le a. Nat Biotechnol. 2021 Mar;39(3):357-367. doi: 10.1038/s41587-020-0707-9. Epub 2020 Oct 19. Nat Biotechnol. 2021. PMID: 33077961 Free PMC article.
1,653 results