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Inhibition of the MYC-Regulated Glutaminase Metabolic Axis Is an Effective Synthetic Lethal Approach for Treating Chemoresistant Ovarian Cancers.
Shen YA, Hong J, Asaka R, Asaka S, Hsu FC, Suryo Rahmanto Y, Jung JG, Chen YW, Yen TT, Tomaszewski A, Zhang C, Attarwala N, DeMarzo AM, Davidson B, Chuang CM, Chen X, Gaillard S, Le A, Shih IM, Wang TL. Shen YA, et al. Among authors: shih im. Cancer Res. 2020 Oct 15;80(20):4514-4526. doi: 10.1158/0008-5472.CAN-19-3971. Epub 2020 Aug 28. Cancer Res. 2020. PMID: 32859605 Free PMC article.
Digital karyotyping identifies thymidylate synthase amplification as a mechanism of resistance to 5-fluorouracil in metastatic colorectal cancer patients.
Wang TL, Diaz LA Jr, Romans K, Bardelli A, Saha S, Galizia G, Choti M, Donehower R, Parmigiani G, Shih IeM, Iacobuzio-Donahue C, Kinzler KW, Vogelstein B, Lengauer C, Velculescu VE. Wang TL, et al. Proc Natl Acad Sci U S A. 2004 Mar 2;101(9):3089-94. doi: 10.1073/pnas.0308716101. Epub 2004 Feb 17. Proc Natl Acad Sci U S A. 2004. PMID: 14970324 Free PMC article.
395 results