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Covalent inhibition of NSD1 histone methyltransferase.
Huang H, Howard CA, Zari S, Cho HJ, Shukla S, Li H, Ndoj J, González-Alonso P, Nikolaidis C, Abbott J, Rogawski DS, Potopnyk MA, Kempinska K, Miao H, Purohit T, Henderson A, Mapp A, Sulis ML, Ferrando A, Grembecka J, Cierpicki T. Huang H, et al. Among authors: henderson a. Nat Chem Biol. 2020 Dec;16(12):1403-1410. doi: 10.1038/s41589-020-0626-6. Epub 2020 Aug 31. Nat Chem Biol. 2020. PMID: 32868895 Free PMC article.
A Synthetic Loop Replacement Peptide That Blocks Canonical NF-κB Signaling.
Bruno PA, Morriss-Andrews A, Henderson AR, Brooks CL 3rd, Mapp AK. Bruno PA, et al. Among authors: henderson ar. Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14997-15001. doi: 10.1002/anie.201607990. Epub 2016 Oct 28. Angew Chem Int Ed Engl. 2016. PMID: 27791341 Free PMC article.
Conservation of coactivator engagement mechanism enables small-molecule allosteric modulators.
Henderson AR, Henley MJ, Foster NJ, Peiffer AL, Beyersdorf MS, Stanford KD, Sturlis SM, Linhares BM, Hill ZB, Wells JA, Cierpicki T, Brooks CL 3rd, Fierke CA, Mapp AK. Henderson AR, et al. Proc Natl Acad Sci U S A. 2018 Sep 4;115(36):8960-8965. doi: 10.1073/pnas.1806202115. Epub 2018 Aug 20. Proc Natl Acad Sci U S A. 2018. PMID: 30127017 Free PMC article.
Gibberellin JRA-003: A Selective Inhibitor of Nuclear Translocation of IKKα.
Annand JR, Henderson AR, Cole KS, Maurais AJ, Becerra J, Liu Y, Weerapana E, Koehler AN, Mapp AK, Schindler CS. Annand JR, et al. ACS Med Chem Lett. 2020 May 21;11(10):1913-1918. doi: 10.1021/acsmedchemlett.9b00613. eCollection 2020 Oct 8. ACS Med Chem Lett. 2020. PMID: 33062173 Free PMC article.
Finerenone, Obesity, and Heart Failure With Mildly Reduced/Preserved Ejection Fraction: Prespecified Analysis of FINEARTS-HF.
Butt JH, Henderson AD, Jhund PS, Claggett BL, Desai AS, Lay-Flurrie J, Viswanathan P, Lage A, Scheerer MF, Lam CSP, Senni M, Shah SJ, Voors AA, Bauersachs J, Fonseca C, Kosiborod MN, Linssen GCM, Petrie MC, Schou M, Verma S, Zannad F, Pitt B, Vaduganathan M, Solomon SD, McMurray JJV. Butt JH, et al. Among authors: henderson ad. J Am Coll Cardiol. 2024 Dec 4:S0735-1097(24)10423-8. doi: 10.1016/j.jacc.2024.10.111. Online ahead of print. J Am Coll Cardiol. 2024. PMID: 39665701 Free article.
2,438 results