Wu YJ - Search Results

1

Synthesis of functionalized derivatives of the gamma-secretase modulator BMS-932481 and identification of its major metabolite.

Zhang Y, Boy KM, Wu YJ, Ramirez A, Toyn JH, Ahlijanian MK, Albright CF, Zhuo X, Johnson BM, Denton RR, Olson RE, Thompson LA 3rd, Macor JE. Zhang Y, et al. Among authors: wu yj. Bioorg Med Chem Lett. 2020 Nov 15;30(22):127530. doi: 10.1016/j.bmcl.2020.127530. Epub 2020 Sep 2. Bioorg Med Chem Lett. 2020. PMID: 32890687

2

Synthesis of fluorinated 1-(3-morpholin-4-yl-phenyl)-ethylamines.

Wu YJ, He H, Sun LQ, Wu D, Gao Q, Li HY. Wu YJ, et al. Among authors: wu d. Bioorg Med Chem Lett. 2003 May 19;13(10):1725-8. doi: 10.1016/s0960-894x(03)00240-3. Bioorg Med Chem Lett. 2003. PMID: 12729651

3

Identification of a potent and selective 5-HT(6) antagonist: one-step synthesis of (E)-3-(benzenesulfonyl)-2- (methylsulfanyl)pyrido[1,2-a]pyrimidin-4-ylidenamine from 2-(benzenesulfonyl)-3,3-bis(methylsulfanyl)acrylonitrile.

Wu YJ, He H, Hu S, Huang Y, Scola PM, Grant-Young K, Bertekap RL, Wu D, Gao Q, Li Y, Klakouski C, Westphal RS. Wu YJ, et al. Among authors: wu d. J Med Chem. 2003 Nov 6;46(23):4834-7. doi: 10.1021/jm034142q. J Med Chem. 2003. PMID: 14584934

4

(S)-N-[1-(4-cyclopropylmethyl-3,4-dihydro-2H-benzo[1,4]oxazin-6-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide is a potent and efficacious KCNQ2 opener which inhibits induced hyperexcitability of rat hippocampal neurons.

Wu YJ, Boissard CG, Chen J, Fitzpatrick W, Gao Q, Gribkoff VK, Harden DG, He H, Knox RJ, Natale J, Pieschl RL, Starrett JE Jr, Sun LQ, Thompson M, Weaver D, Wu D, Dworetzky SI. Wu YJ, et al. Among authors: wu d. Bioorg Med Chem Lett. 2004 Apr 19;14(8):1991-5. doi: 10.1016/j.bmcl.2004.01.069. Bioorg Med Chem Lett. 2004. PMID: 15050644

5

Synthesis and KCNQ2 opener activity of N-(1-benzo[1,3]dioxol-5-yl-ethyl, N-[1-(2,3-dihydro-benzofuran-5-yl)-ethyl, and N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl acrylamides.

Wu YJ, Sun LQ, He H, Chen J, Starrett JE Jr, Dextraze P, Daris JP, Boissard CG, Pieschl RL, Gribkoff VK, Natale J, Knox RJ, Harden DG, Thompson MW, Fitzpatrick W, Weaver D, Wu D, Gao Q, Dworetzky SI. Wu YJ, et al. Among authors: wu d. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4533-7. doi: 10.1016/j.bmcl.2004.06.035. Bioorg Med Chem Lett. 2004. PMID: 15357987

6

(S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity.

L'Heureux A, Martel A, He H, Chen J, Sun LQ, Starrett JE, Natale J, Dworetzky SI, Knox RJ, Harden DG, Weaver D, Thompson MW, Wu YJ. L'Heureux A, et al. Among authors: wu yj. Bioorg Med Chem Lett. 2005 Jan 17;15(2):363-6. doi: 10.1016/j.bmcl.2004.10.065. Bioorg Med Chem Lett. 2005. PMID: 15603955

7

Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE.

Wu YJ, Zhang Y, Good AC, Burton CR, Toyn JH, Albright CF, Macor JE, Thompson LA. Wu YJ, et al. Bioorg Med Chem Lett. 2009 May 15;19(10):2654-60. doi: 10.1016/j.bmcl.2009.03.144. Epub 2009 Apr 5. Bioorg Med Chem Lett. 2009. PMID: 19375914

8

Discovery of disubstituted piperidines and homopiperidines as potent dual NK1 receptor antagonists-serotonin reuptake transporter inhibitors for the treatment of depression.

Wu YJ, He H, Bertekap R, Westphal R, Lelas S, Newton A, Wallace T, Taber M, Davis C, Macor JE, Bronson J. Wu YJ, et al. Bioorg Med Chem. 2013 Apr 15;21(8):2217-2228. doi: 10.1016/j.bmc.2013.02.010. Epub 2013 Feb 19. Bioorg Med Chem. 2013. PMID: 23477943

9

Discovery of (S,E)-3-(2-fluorophenyl)-N-(1-(3-(pyridin-3-yloxy)phenyl)ethyl)-acrylamide as a potent and efficacious KCNQ2 (Kv7.2) opener for the treatment of neuropathic pain.

Wu YJ, Conway CM, Sun LQ, Machet F, Chen J, Chen P, He H, Bourin C, Calandra V, Polino JL, Davis CD, Heman K, Gribkoff VK, Boissard CG, Knox RJ, Thompson MW, Fitzpatrick W, Weaver D, Harden DG, Natale J, Dworetzky SI, Starrett JE Jr. Wu YJ, et al. Bioorg Med Chem Lett. 2013 Nov 15;23(22):6188-91. doi: 10.1016/j.bmcl.2013.08.092. Epub 2013 Sep 8. Bioorg Med Chem Lett. 2013. PMID: 24070783

10

Structure activity relationship studies of 3-arylsulfonyl-pyrido[1,2-a]pyrimidin-4-imines as potent 5-HT₆ antagonists.

Hu S, Huang Y, Wu YJ, He H, Grant-Young KA, Bertekap RL, Whiterock V, Brassil P, Lentz K, Sivaprakasam P, Langley DR, Westphal RS, Scola PM. Hu S, et al. Among authors: wu yj. Bioorg Med Chem. 2014 Mar 1;22(5):1782-90. doi: 10.1016/j.bmc.2014.01.003. Epub 2014 Jan 9. Bioorg Med Chem. 2014. PMID: 24495863

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