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Feasibility of intracerebrally administering multiple doses of genetically modified neural stem cells to locally produce chemotherapy in glioma patients.
Portnow J, Badie B, Suzette Blanchard M, Kilpatrick J, Tirughana R, Metz M, Mi S, Tran V, Ressler J, D'Apuzzo M, Aboody KS, Synold TW. Portnow J, et al. Among authors: metz m. Cancer Gene Ther. 2021 Apr;28(3-4):294-306. doi: 10.1038/s41417-020-00219-y. Epub 2020 Sep 8. Cancer Gene Ther. 2021. PMID: 32895489 Free PMC article.
Human Neural Stem Cell Biodistribution and Predicted Tumor Coverage by a Diffusible Therapeutic in a Mouse Glioma Model.
Barish ME, Herrmann K, Tang Y, Argalian Herculian S, Metz M, Aramburo S, Tirughana R, Gutova M, Annala A, Moats RA, Goldstein L, Rockne RC, Gutierrez J, Brown CE, Ghoda L, Aboody KS. Barish ME, et al. Among authors: metz m. Stem Cells Transl Med. 2017 Jun;6(6):1522-1532. doi: 10.1002/sctm.16-0397. Epub 2017 May 8. Stem Cells Transl Med. 2017. PMID: 28481046 Free PMC article.
Neural stem cell-mediated enzyme/prodrug therapy for glioma: preclinical studies.
Aboody KS, Najbauer J, Metz MZ, D'Apuzzo M, Gutova M, Annala AJ, Synold TW, Couture LA, Blanchard S, Moats RA, Garcia E, Aramburo S, Valenzuela VV, Frank RT, Barish ME, Brown CE, Kim SU, Badie B, Portnow J. Aboody KS, et al. Among authors: metz mz. Sci Transl Med. 2013 May 8;5(184):184ra59. doi: 10.1126/scitranslmed.3005365. Sci Transl Med. 2013. PMID: 23658244 Free PMC article.
Neural Stem Cell-Based Anticancer Gene Therapy: A First-in-Human Study in Recurrent High-Grade Glioma Patients.
Portnow J, Synold TW, Badie B, Tirughana R, Lacey SF, D'Apuzzo M, Metz MZ, Najbauer J, Bedell V, Vo T, Gutova M, Frankel P, Chen M, Aboody KS. Portnow J, et al. Among authors: metz mz. Clin Cancer Res. 2017 Jun 15;23(12):2951-2960. doi: 10.1158/1078-0432.CCR-16-1518. Epub 2016 Dec 15. Clin Cancer Res. 2017. PMID: 27979915 Free PMC article. Clinical Trial.
Optimization of a Neural Stem-Cell-Mediated Carboxylesterase/Irinotecan Gene Therapy for Metastatic Neuroblastoma.
Gutova M, Goldstein L, Metz M, Hovsepyan A, Tsurkan LG, Tirughana R, Tsaturyan L, Annala AJ, Synold TW, Wan Z, Seeger R, Anderson C, Moats RA, Potter PM, Aboody KS. Gutova M, et al. Among authors: metz m. Mol Ther Oncolytics. 2016 Dec 14;4:67-76. doi: 10.1016/j.omto.2016.11.004. eCollection 2017 Mar 17. Mol Ther Oncolytics. 2016. PMID: 28345025 Free PMC article.
Neural stem cell tropism to glioma: critical role of tumor hypoxia.
Zhao D, Najbauer J, Garcia E, Metz MZ, Gutova M, Glackin CA, Kim SU, Aboody KS. Zhao D, et al. Among authors: metz mz. Mol Cancer Res. 2008 Dec;6(12):1819-29. doi: 10.1158/1541-7786.MCR-08-0146. Mol Cancer Res. 2008. PMID: 19074827 Free article.
738 results