Drosten M - Search Results

1

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas.

Esteban-Burgos L, Wang H, Nieto P, Zheng J, Blanco-Aparicio C, Varela C, Gómez-López G, Fernández-García F, Sanclemente M, Guerra C, Drosten M, Galán J, Caleiras E, Martínez-Torrecuadrada J, Fajas L, Peng SB, Santamaría D, Musteanu M, Barbacid M. Esteban-Burgos L, et al. Among authors: drosten m. Proc Natl Acad Sci U S A. 2020 Sep 29;117(39):24415-24426. doi: 10.1073/pnas.2002520117. Epub 2020 Sep 10. Proc Natl Acad Sci U S A. 2020. PMID: 32913049 Free PMC article.

2

Using cells devoid of RAS proteins as tools for drug discovery.

Urosevic J, Sum EY, Moneo V, Drosten M, Dhawahir A, Becerra M, Carnero A, Barbacid M. Urosevic J, et al. Among authors: drosten m. Mol Carcinog. 2009 Nov;48(11):1038-47. doi: 10.1002/mc.20555. Mol Carcinog. 2009. PMID: 19526460

3

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

Drosten M, Dhawahir A, Sum EY, Urosevic J, Lechuga CG, Esteban LM, Castellano E, Guerra C, Santos E, Barbacid M. Drosten M, et al. EMBO J. 2010 Mar 17;29(6):1091-104. doi: 10.1038/emboj.2010.7. Epub 2010 Feb 11. EMBO J. 2010. PMID: 20150892 Free PMC article.

4

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

Matallanas D, Romano D, Al-Mulla F, O'Neill E, Al-Ali W, Crespo P, Doyle B, Nixon C, Sansom O, Drosten M, Barbacid M, Kolch W. Matallanas D, et al. Among authors: drosten m. Mol Cell. 2011 Dec 23;44(6):893-906. doi: 10.1016/j.molcel.2011.10.016. Mol Cell. 2011. PMID: 22195963 Free article.

5

Ras signaling is essential for skin development.

Drosten M, Lechuga CG, Barbacid M. Drosten M, et al. Oncogene. 2014 May 29;33(22):2857-65. doi: 10.1038/onc.2013.254. Epub 2013 Jul 8. Oncogene. 2014. PMID: 23831572

6

Genetic analysis of Ras genes in epidermal development and tumorigenesis.

Drosten M, Lechuga CG, Barbacid M. Drosten M, et al. Small GTPases. 2013 Oct-Dec;4(4):236-41. doi: 10.4161/sgtp.26905. Epub 2013 Oct 22. Small GTPases. 2013. PMID: 24150175 Free PMC article. Review.

7

Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications.

Azrak SS, Ginel-Picardo A, Drosten M, Barbacid M, Santos E. Azrak SS, et al. Among authors: drosten m. BMC Genomics. 2013 Oct 25;14:731. doi: 10.1186/1471-2164-14-731. BMC Genomics. 2013. PMID: 24156637 Free PMC article.

8

Ras in epidermal proliferation.

Drosten M, Lechuga CG, Barbacid M. Drosten M, et al. Oncotarget. 2014 Jul 30;5(14):5194-5. doi: 10.18632/oncotarget.2275. Oncotarget. 2014. PMID: 25114036 Free PMC article. No abstract available.

9

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway.

Drosten M, Sum EY, Lechuga CG, Simón-Carrasco L, Jacob HK, García-Medina R, Huang S, Beijersbergen RL, Bernards R, Barbacid M. Drosten M, et al. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15155-60. doi: 10.1073/pnas.1417549111. Epub 2014 Oct 6. Proc Natl Acad Sci U S A. 2014. PMID: 25288756 Free PMC article.

10

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets.

Drosten M, Barbacid M. Drosten M, et al. J Mol Med (Berl). 2016 Feb;94(2):121-35. doi: 10.1007/s00109-015-1360-5. Epub 2015 Nov 3. J Mol Med (Berl). 2016. PMID: 26526121 Review.

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