Roth DM - Search Results

1

The sustained expression of Cas9 targeting toxic RNAs reverses disease phenotypes in mouse models of myotonic dystrophy type 1.

Batra R, Nelles DA, Roth DM, Krach F, Nutter CA, Tadokoro T, Thomas JD, Sznajder ŁJ, Blue SM, Gutierrez HL, Liu P, Aigner S, Platoshyn O, Miyanohara A, Marsala M, Swanson MS, Yeo GW. Batra R, et al. Among authors: roth dm. Nat Biomed Eng. 2021 Feb;5(2):157-168. doi: 10.1038/s41551-020-00607-7. Epub 2020 Sep 14. Nat Biomed Eng. 2021. PMID: 32929188 Free PMC article.

2

Q-bodies monitor the quinary state of the protein fold.

Roth DM, Balch WE. Roth DM, et al. Nat Cell Biol. 2013 Oct;15(10):1137-9. doi: 10.1038/ncb2857. Nat Cell Biol. 2013. PMID: 24084862

3

Modeling general proteostasis: proteome balance in health and disease.

Roth DM, Balch WE. Roth DM, et al. Curr Opin Cell Biol. 2011 Apr;23(2):126-34. doi: 10.1016/j.ceb.2010.11.001. Epub 2010 Dec 3. Curr Opin Cell Biol. 2011. PMID: 21131189 Free PMC article. Review.

4

Emergent properties of proteostasis in managing cystic fibrosis.

Balch WE, Roth DM, Hutt DM. Balch WE, et al. Among authors: roth dm. Cold Spring Harb Perspect Biol. 2011 Feb 1;3(2):a004499. doi: 10.1101/cshperspect.a004499. Cold Spring Harb Perspect Biol. 2011. PMID: 21421917 Free PMC article. Review.

5

Modulation of the maladaptive stress response to manage diseases of protein folding.

Roth DM, Hutt DM, Tong J, Bouchecareilh M, Wang N, Seeley T, Dekkers JF, Beekman JM, Garza D, Drew L, Masliah E, Morimoto RI, Balch WE. Roth DM, et al. PLoS Biol. 2014 Nov 18;12(11):e1001998. doi: 10.1371/journal.pbio.1001998. eCollection 2014 Nov. PLoS Biol. 2014. PMID: 25406061 Free PMC article.

6

FK506 binding protein 8 peptidylprolyl isomerase activity manages a late stage of cystic fibrosis transmembrane conductance regulator (CFTR) folding and stability.

Hutt DM, Roth DM, Chalfant MA, Youker RT, Matteson J, Brodsky JL, Balch WE. Hutt DM, et al. Among authors: roth dm. J Biol Chem. 2012 Jun 22;287(26):21914-25. doi: 10.1074/jbc.M112.339788. Epub 2012 Apr 2. J Biol Chem. 2012. PMID: 22474283 Free PMC article.

7

Silencing of the Hsp70-specific nucleotide-exchange factor BAG3 corrects the F508del-CFTR variant by restoring autophagy.

Hutt DM, Mishra SK, Roth DM, Larsen MB, Angles F, Frizzell RA, Balch WE. Hutt DM, et al. Among authors: roth dm. J Biol Chem. 2018 Aug 31;293(35):13682-13695. doi: 10.1074/jbc.RA118.002607. Epub 2018 Jul 9. J Biol Chem. 2018. PMID: 29986884 Free PMC article.

8

Correcting the F508del-CFTR variant by modulating eukaryotic translation initiation factor 3-mediated translation initiation.

Hutt DM, Loguercio S, Roth DM, Su AI, Balch WE. Hutt DM, et al. Among authors: roth dm. J Biol Chem. 2018 Aug 31;293(35):13477-13495. doi: 10.1074/jbc.RA118.003192. Epub 2018 Jul 13. J Biol Chem. 2018. PMID: 30006345 Free PMC article.

9

The histone deacetylase inhibitor, Vorinostat, represses hypoxia inducible factor 1 alpha expression through translational inhibition.

Hutt DM, Roth DM, Vignaud H, Cullin C, Bouchecareilh M. Hutt DM, et al. Among authors: roth dm. PLoS One. 2014 Aug 28;9(8):e106224. doi: 10.1371/journal.pone.0106224. eCollection 2014. PLoS One. 2014. PMID: 25166596 Free PMC article.

10

E-cigarette-induced changes in cell stress and mitochondrial function.

Chitteti R, Zuniga-Hertz JP, Masso-Silva JA, Shin J, Niesman I, Bojanowski CM, Kumar AJ, Hepokoski M, Crotty Alexander LE, Patel HH, Roth DM. Chitteti R, et al. Among authors: roth dm. Free Radic Biol Med. 2025 Jan 3;228:329-338. doi: 10.1016/j.freeradbiomed.2025.01.004. Online ahead of print. Free Radic Biol Med. 2025. PMID: 39756490 Free article.

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